發(fā)明專利：
發(fā)明公開：
[1]宋永相,楊佳凡,周鎮(zhèn)檳,李曉悅,馬俊英,閆巖,鞠建華. 一類異腈基化合物及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N115894307A,2023-04-04.
[2]鞠建華,蔡存磊,陳盈盈,孫長利,馬俊英. 兩個二苯醚化合物及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N115710167A,2023-02-24.
[3]馬俊英,喬伊君,鞠建華,楊佳凡,宋永相. 一株海洋鏈霉菌及其環(huán)八肽化合物在制備抗耐藥菌藥物中的應(yīng)用[P]. 廣東�。篊N115124597A,2022-09-30.
[4]安法梁,鄭高帆,朱云飛,鞠建華,馬俊英. 深海鏈霉菌基因工程突變株生產(chǎn)怡萊霉素E的高產(chǎn)培養(yǎng)基及其規(guī)�；l(fā)酵工藝[P]. 上海市：CN114540446A,2022-05-27.
[5]鞠建華,周鎮(zhèn)檳,楊佳凡,宋永相,田新朋. 兩個大環(huán)內(nèi)酯化合物及其在制備抗菌、抗癌藥物中的應(yīng)用[P]. 廣東�。篊N114437155A,2022-05-06.
[6]鞠建華,宋永相,楊佳凡. 一類骨架新穎的6/6/6/6/5/5環(huán)生物堿類化合物及其在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N114349762A,2022-04-15.
[7]宋永相,鞠建華,劉田,李潔,楊佳凡,李曉悅,盧瓊,楊青. 深海放線菌11791在制備防治農(nóng)牧業(yè)鱗翅目害蟲藥物中的應(yīng)用[P]. 廣東�。篊N114009451A,2022-02-08.
[8]李青連,鞠建華,梁智鋮,李駿,凌春耀. 4’-N-demethyl-vicenistatin及其制備方法和應(yīng)用[P]. 廣東省：CN113912658A,2022-01-11.
[9]楊青,劉田,宋永相,盧瓊,鞠建華. 雙吲哚吡咯類化合物的應(yīng)用[P]. 廣東�。篊N113207883A,2021-08-06.
[10]李青連,許潤,宋永相,李駿,鞠建華. 一種環(huán)六肽化合物desotamide A4及其在制備抗菌藥物中的應(yīng)用[P]. 廣東省：CN113150077A,2021-07-23.
[11]馬俊英,朱湘成,段燕文,鞠建華. 一種化合物ilamycin E-1/E-2的微生物發(fā)酵制備方法[P]. 廣東�。篊N113122599A,2021-07-16.
[12]鞠建華,邵明偉,孫長利,李青連,王曉雪. 一種海洋真菌-細菌共生體及其代謝產(chǎn)物和在制備抗菌藥物中的應(yīng)用[P]. 廣東省：CN112694983A,2021-04-23.
[13]安法梁,鄭高帆,朱云飛,鞠建華,馬俊英. 利用深海鏈霉菌生產(chǎn)怡萊霉素E的培養(yǎng)基及其制備方法[P]. 上海市：CN112608965A,2021-04-06.
[14]鞠建華,李駿,劉志永,馬俊英,張?zhí)煊? 一種怡萊霉素F衍生物及其在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東�。篊N111647050A,2020-09-11.
[15]鞠建華,張?zhí)煊?孫長利,劉志永,馬俊英. 海洋環(huán)肽化合物及其在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東省：CN111303247A,2020-06-19.
[16]鞠建華,陳姜,桂春,李青連,田新朋. 一種定向生產(chǎn)抗病毒和抗菌活性化合物的基因工程菌株及其應(yīng)用[P]. 廣東�。篊N111269867A,2020-06-12.
[17]宋永相,楊佳凡,賴添財,鞠建華. 深海放線菌生物制劑在制備預(yù)防柑橘潰瘍疾病藥物中的應(yīng)用[P]. 廣東�。篊N111096337A,2020-05-05.
[18]鞠建華,劉夢嬋,孫長利,馬俊英,李青連. 一類雙脫甲基放線菌素衍生物及其在制備抗耐藥菌感染藥物中的應(yīng)用[P]. 廣東�。篊N110669103A,2020-01-10.
[19]馬俊英,鞠建華,黃洪波,張春燕,賈艷璽,李巖. 化合物ilamycin F及其應(yīng)用[P]. 廣東�。篊N110218244A,2019-09-10.
[20]馬俊英,張華,解青,鞠建華. 化合物ilamycin C及其同系物在制備治療三陰乳腺癌藥物中的應(yīng)用[P]. 廣東�。篊N109985229A,2019-07-09.
[21]鞠建華,孫長利,張善文,桂春,張華. 一類安莎全碳環(huán)聚酮類抗生素及其在制備抗菌藥物或抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N109810919A,2019-05-28.
[22]馬俊英,孫長利,劉志勇,張?zhí)煊?鞠建華. 環(huán)肽類抗生素及其制備方法和在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東省：CN109762046A,2019-05-17.
[23]鞠建華,張善文,桂春,邵明偉,黃洪波. 一種海洋鏈霉菌、衣霉素類化合物及其制備方法[P]. 廣東：CN108660093A,2018-10-16.
[24]李青連,鞠建華,秦湘靜,劉靜. 一種高產(chǎn)環(huán)肽類化合物的菌株[P]. 廣東：CN108587991A,2018-09-28.
[25]鞠建華,張善文,田新朋,桂春,秦湘靜,黃洪波. 一種海洋糖多孢菌及其在制備紅霉素衍生物中的應(yīng)用[P]. 廣東：CN108485991A,2018-09-04.
[26]李青連,鞠建華,秦湘靜,劉靜. 一種高產(chǎn)含有L-Val結(jié)構(gòu)單元的化合物的菌株△mfnH[P]. 廣東：CN108486028A,2018-09-04.
[27]鄧音樂,鞠建華,蒙麗麗,孫長利,趙朔,孫秀云,陳俐. 化合物Sorbicillin在防治白色念珠菌中的應(yīng)用[P]. 廣東：CN108338979A,2018-07-31.
[28]鄧音樂,鞠建華,蒙麗麗,孫長利,趙朔,孫秀云,陳俐. 一種防治白色念珠菌化合物及其制備方法與應(yīng)用[P]. 廣東：CN108191693A,2018-06-22.
[29]鞠建華,潘華奇,田新朋. 一種多功能暹羅芽孢桿菌及其生物活性物質(zhì)的制備和應(yīng)用[P]. 廣東：CN108060100A,2018-05-22.
[30]鞠建華,宋永相,李潔,黃洪波. 一類角環(huán)素化合物及其在制備抗腫瘤或抗菌藥物中的應(yīng)用[P]. 廣東：CN106834160A,2017-06-13.
[31]鞠建華,宋永相,李青連,胡云峰. 一類大環(huán)內(nèi)酯化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN106632221A,2017-05-10.
[32]鞠建華,馬俊英,黃洪波,張春燕,賈艷璽,李巖. 一種定向生產(chǎn)抗結(jié)核活性和抗腫瘤活性化合物的基因工程菌株及其應(yīng)用[P]. 廣東：CN106497827A,2017-03-15.
[33]鞠建華,馬俊英,黃洪波,賈艷璽,張春燕. 環(huán)肽類化合物在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN106397544A,2017-02-15.
[34]鞠建華,張?zhí)煊?馬俊英,劉永志. 一種海洋鏈霉菌、及其環(huán)肽化合物在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東：CN106279370A,2017-01-04.
[35]鞠建華,桂春,李青連,程偉鴿. 一種海洋鏈霉菌及其在制備那西肽中的應(yīng)用[P]. 廣東：CN106119157A,2016-11-16.
[36]鞠建華,宋永相,謝運昌,秦湘靜. 一種利用深海鏈霉菌SCSIO 5604制備抗生素dihydrotetrodecamycin的方法[P]. 廣東：CN105925637A,2016-09-07.
[37]李文均,劉晴,陳微,高銳,段焰青,侯偉,鞠建華. 一株擬無枝菌酸菌及利用該菌制備特戊依羅霉素的方法[P]. 廣東：CN105886421A,2016-08-24.
[38]鞠建華,宋永相,許芳. 一類環(huán)六肽化合物及其在制備抗良性前列腺增生藥物中的應(yīng)用[P]. 廣東：CN105294842A,2016-02-03.
[39]鞠建華,李青連,秦湘靜,劉靜. 氨基轉(zhuǎn)移酶和異構(gòu)酶在催化形成L-allo-Ile中的應(yīng)用[P]. 廣東：CN105154487A,2015-12-16.
[40]鞠建華,朱清華,黃洪波,宋永相,馬俊英,李青連. 一類核苷類抗生素及其在制備抗菌藥物中的應(yīng)用[P]. 廣東：CN105061537A,2015-11-18.
[41]鞠建華,謝運昌. 一種灰綠霉素與綠灰霉素高產(chǎn)菌株及其構(gòu)建方法[P]. 廣東：CN104962578A,2015-10-07.
[42]張永光,李文均,劉晴,宋永相,鞠建華,王宏飛,李麗,張元明,郭建偉. 一種生產(chǎn)安薩菌素P-3及15-羥基衍生物的擬諾卡氏菌及其制備方法和應(yīng)用[P]. 新疆：CN104877929A,2015-09-02.
[43]鞠建華,宋永相,李潔,黃洪波. 一類角環(huán)素化合物及其在制備抗腫瘤或抗菌藥物中的應(yīng)用[P]. 廣東：CN104744533A,2015-07-01.
[44]鞠建華,張幸,桂春. 一種海洋鏈霉菌及其應(yīng)用[P]. 廣東：CN104630116A,2015-05-20.
[45]張幸,羅明和,鞠建華. 一種吲哚-3-甲醛類化合物的制備方法和應(yīng)用[P]. 廣東：CN104402792A,2015-03-11.
[46]鞠建華,馬俊英,張云,李青連,黃洪波,宋永相,王博,謝運昌. 環(huán)酯肽類抗生素黑莫他丁的高產(chǎn)菌株及其構(gòu)建方法[P]. 廣東：CN104164399A,2014-11-26.
[47]張偲,田新朋,鞠建華,羅明和,尹浩. 一種海洋鏈霉菌及利用其制備Enterocin的方法以及該菌的應(yīng)用[P]. 廣東：CN104087523A,2014-10-08.
[48]鞠建華,丁杰,宋永相. 一種生物堿類化合物的制備方法及其在制備抑制鈣離子通道藥物中的應(yīng)用[P]. 廣東：CN103408503A,2013-11-27.
[49]鞠建華,宋永相,黃洪波,張云. 兩個環(huán)六肽化合物及其在制備抗菌藥物中的應(yīng)用[P]. 廣東：CN103396476A,2013-11-20.
[50]鞠建華,宋永相,黃洪波,張云. 一類萘醌倍半萜化合物及其在制備抗腫瘤或抗菌藥物中的應(yīng)用[P]. 廣東：CN103396389A,2013-11-20.
[51]鞠建華,宋永相,黃洪波,張云. 一類吩嗪化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN103360329A,2013-10-23.
[52]鞠建華,陳奇,紀(jì)昌濤. 一種海洋咔啉生物堿的生物合成基因簇及其應(yīng)用[P]. 廣東：CN103275976A,2013-09-04.
[53]鞠建華,張云,黃洪波,劉靜,馬俊英. 一種格瑞克霉素和P-1894B的生物合成基因簇及其應(yīng)用[P]. 廣東：CN103215281A,2013-07-24.
[54]鞠建華,謝運昌. 灰綠霉素和綠灰霉素的生物合成基因簇及其應(yīng)用[P]. 廣東：CN102911957A,2013-02-06.
[55]鞠建華,周瀟,黃洪波. 抗生素Tetrathiazomycin A及其制備方法和在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102775427A,2012-11-14.
[56]張長生,張慶波,李蘇梅,田新朋,張文軍,張海波,李惠賢,張偲,鞠建華. 鏈霉菌和吲哚倍半萜類化合物及其制備方法和在制備抗菌抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102757908A,2012-10-31.
[57]鞠建華,周瀟,黃洪波,劉靜. 一類環(huán)肽抗生素及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東：CN102746376A,2012-10-24.
[58]張長生,李慧賢,張慶波,李蘇梅,朱義廣,張光濤,張海波,田新朋,張偲,鞠建華. 廈霉素A和氧廈霉素的生物合成基因簇及其應(yīng)用[P]. 廣東：CN102732534A,2012-10-17.
[59]張長生,張文軍,田新朋,李蘇梅,張慶波,馬亮,張海波,張偲,鞠建華. 鏈霉菌、抗腫瘤化合物Spiro-Indimycin A-D及其制備方法和應(yīng)用[P]. 廣東：CN102643765A,2012-08-22.
[60]張長生,張海波,李蘇梅,張改云,張光濤,朱義廣,陳瑞東,肖吉,鞠建華. 友菌素的生物合成基因簇及其應(yīng)用[P]. 廣東：CN102533813A,2012-07-04.
[61]鞠建華,陳子明,黃洪波,宋永相,張長生. 環(huán)七肽類化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102516368A,2012-06-27.
[62]鞠建華,黃洪波,任香梅,宋永相,張長生. 一類角環(huán)素類化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102492006A,2012-06-13.
[63]鞠建華,陳子明,黃洪波,宋永相,張長生. 霉酚酸衍生物Penicacids A、B、C及其在制備免疫抑制藥物中的應(yīng)用[P]. 廣東：CN102391225A,2012-03-28.
[64]鞠建華,朱清華,李軍,馬俊英,田新朋,張長生. 一種核苷類抗生素A201A高產(chǎn)菌株及其構(gòu)建方法[P]. 廣東：CN102373171A,2012-03-14.
[65]張長生,李蘇梅,田新朋,張文軍,張海波,張光濤,張偲,鞠建華. 抗生素Pseudonocardian A和B及其制備方法和在制備抗菌、抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102351859A,2012-02-15.
[66]張長生,李蘇梅,牛四文,田新朋,張海波,張光濤,張偲,鞠建華. 抗生素Lobophorin E和F及其制備方法和在制備抗菌、抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102321133A,2012-01-18.
[67]張偲,張長生,田新朋,李蘇梅,張文軍,張海波,張光濤,尹浩,鞠建華. 一種假諾卡氏菌及利用其制備Deoxynyboquinone的方法[P]. 廣東：CN102296039A,2011-12-28.
[68]鞠建華,黃洪波,姚月良,田新朋,張長生. β-咔啉生物堿及其在制備抗瘧疾藥物中的應(yīng)用[P]. 廣東：CN102250089A,2011-11-23.
[69]張長生,李蘇梅,牛四文,胡濤,張光濤,肖毅,張海波,鞠建華. 六種臺勾霉素類化合物及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東：CN102219815A,2011-10-19.
[70]鞠建華,周俊勇,黃洪波,馬俊英,王博,汪中文,田新朋,張偲,張長生. 一種海洋鏈霉菌及利用其制備星形孢菌素和K-252d的方法[P]. 廣東：CN102181387A,2011-09-14.
[71]張長生,李蘇梅,田新朋,牛四文,鞠建華,張偲. 一種鏈霉菌及利用該菌制備多種抗生素的工藝[P]. 廣東：CN102168044A,2011-08-31.
[72]鞠建華,姚月良,田新朋,張長生,張偲. 一種海洋鏈霉菌以及利用該菌制備替達霉素A和B的方法[P]. 廣東：CN102168034A,2011-08-31.
[73]張長生,肖毅,李蘇梅,牛四文,張光濤,張海波,胡濤,鞠建華. 臺勾霉素的生物合成基因簇及其應(yīng)用[P]. 廣東：CN102115757A,2011-07-06.
[74]張長生,李蘇梅,肖毅,牛四文,鞠建華. 四種臺勾霉素類化合物及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東：CN102030791A,2011-04-27.
[75]張長生,李蘇梅,田新朋,牛四文,張文軍,鞠建華,張偲. 一種鏈霉菌及利用該菌發(fā)酵制備抗霉素類抗生素的工藝[P]. 廣東：CN101974464A,2011-02-16.
[76]楊峻山,鞠建華,王立為,肖培根. 枇杷葉總?cè)扑峤M分及其在制備抗炎、止咳藥物中的應(yīng)用[P]. 北京：CN1439648,2003-09-03.
[77]楊峻山,鞠建華. 一種環(huán)菠蘿蜜烷三萜皂甙新化合物及其在免疫抑制和腫瘤治療中的應(yīng)用[P]. 北京：CN1342656,2002-04-03.
[78]楊峻山,鞠建華. 一種環(huán)菠蘿蜜烷三萜皂甙新化合物及其在心血管病治療中的應(yīng)用[P]. 北京：CN1332175,2002-01-23.
發(fā)明授權(quán)：
[1]李青連,許潤,宋永相,李駿,鞠建華. 一種環(huán)六肽化合物desotamide A4及其在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N113150077B,2023-06-06.
[2]鞠建華,宋永相,楊佳凡. 一類骨架新穎的6/6/6/6/5/5環(huán)生物堿類化合物及其在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N114349762B,2023-01-03.
[3]鞠建華,周鎮(zhèn)檳,楊佳凡,宋永相,田新朋. 兩個大環(huán)內(nèi)酯化合物及其在制備抗菌、抗癌藥物中的應(yīng)用[P]. 廣東�。篊N114437155B,2022-09-20.
[4]宋永相,鞠建華,劉田,李潔,楊佳凡,李曉悅,盧瓊,楊青. 深海放線菌11791在制備防治農(nóng)牧業(yè)鱗翅目害蟲藥物中的應(yīng)用[P]. 廣東省：CN114009451B,2022-09-06.
[5]安法梁,鄭高帆,朱云飛,鞠建華,馬俊英. 利用深海鏈霉菌生產(chǎn)怡萊霉素E的培養(yǎng)基及其制備方法[P]. 上海市：CN112608965B,2022-08-05.
[6]鞠建華,陳姜,桂春,李青連,田新朋. 一種定向生產(chǎn)抗病毒和抗菌活性化合物的基因工程菌株及其應(yīng)用[P]. 廣東�。篊N111269867B,2022-05-10.
[7]鞠建華,邵明偉,孫長利,李青連,王曉雪. 一種海洋真菌-細菌共生體及其代謝產(chǎn)物和在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N112694983B,2022-05-06.
[8]楊青,劉田,宋永相,盧瓊,鞠建華. 雙吲哚吡咯類化合物的應(yīng)用[P]. 廣東�。篊N113207883B,2022-04-15.
[9]鞠建華,張?zhí)煊?孫長利,劉志永,馬俊英. 海洋環(huán)肽化合物及其在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東�。篊N111303247B,2022-03-22.
[10]鞠建華,李駿,劉志永,馬俊英,張?zhí)煊? 一種怡萊霉素F衍生物及其在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東�。篊N111647050B,2021-11-09.
[11]鞠建華,張善文,桂春,邵明偉,黃洪波. 一種海洋鏈霉菌、衣霉素類化合物及其制備方法[P]. 廣東�。篊N108660093B,2021-07-20.
[12]李青連,鞠建華,秦湘靜,劉靜. 一種高產(chǎn)含有L-Val結(jié)構(gòu)單元的化合物的菌株△mfnH[P]. 廣東省：CN108486028B,2021-06-01.
[13]鞠建華,張善文,田新朋,桂春,秦湘靜,黃洪波. 一種海洋糖多孢菌及其在制備紅霉素衍生物中的應(yīng)用[P]. 廣東�。篊N108485991B,2021-05-18.
[14]馬俊英,鞠建華,黃洪波,張春燕,賈艷璽,李巖. 化合物ilamycin F及其應(yīng)用[P]. 廣東省：CN110218244B,2021-04-09.
[15]馬俊英,張華,解青,鞠建華. 化合物ilamycin C及其同系物在制備治療三陰乳腺癌藥物中的應(yīng)用[P]. 廣東�。篊N109985229B,2021-04-06.
[16]李青連,鞠建華,秦湘靜,劉靜. 一種高產(chǎn)環(huán)肽類化合物的菌株[P]. 廣東省：CN108587991B,2021-03-05.
[17]鞠建華,孫長利,張善文,桂春,張華. 一類安莎全碳環(huán)聚酮類抗生素及其在制備抗菌藥物或抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N109810919B,2021-02-09.
[18]鞠建華,潘華奇,田新朋. 一種多功能暹羅芽孢桿菌及其生物活性物質(zhì)的制備和應(yīng)用[P]. 廣東�。篊N108060100B,2021-01-29.
[19]宋永相,楊佳凡,賴添財,鞠建華. 深海放線菌生物制劑在制備預(yù)防柑橘潰瘍疾病藥物中的應(yīng)用[P]. 廣東�。篊N111096337B,2020-11-10.
[20]馬俊英,孫長利,劉志勇,張?zhí)煊?鞠建華. 環(huán)肽類抗生素及其制備方法和在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東�。篊N109762046B,2020-10-23.
[21]鄧音樂,鞠建華,蒙麗麗,孫長利,趙朔,孫秀云,陳俐. 一種防治白色念珠菌化合物及其制備方法與應(yīng)用[P]. 廣東�。篊N108191693B,2020-06-12.
[22]鞠建華,宋永相,李青連,胡云峰. 一類大環(huán)內(nèi)酯化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N106632221B,2020-01-31.
[23]鞠建華,宋永相,李潔,黃洪波. 一種產(chǎn)角環(huán)素化合物的紅灰鏈霉菌[P]. 廣東�。篊N106834160B,2019-12-31.
[24]鞠建華,張?zhí)煊?馬俊英,劉永志. 一種海洋鏈霉菌、及其環(huán)肽化合物在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東�。篊N106279370B,2019-09-27.
[25]鞠建華,馬俊英,黃洪波,賈艷璽,張春燕. 環(huán)肽類化合物在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東省：CN106397544B,2019-09-27.
[26]鞠建華,宋永相,謝運昌,秦湘靜. 一種利用深海鏈霉菌SCSIO 5604制備抗生素dihydrotetrodecamycin的方法[P]. 廣東�。篊N105925637B,2019-09-03.
[27]鞠建華,桂春,李青連,程偉鴿. 一種海洋鏈霉菌及其在制備那西肽中的應(yīng)用[P]. 廣東省：CN106119157B,2019-08-13.
[28]鞠建華,馬俊英,黃洪波,張春燕,賈艷璽,李巖. 一種定向生產(chǎn)抗結(jié)核活性和抗腫瘤活性化合物的基因工程菌株及其應(yīng)用[P]. 廣東�。篊N106497827B,2019-08-02.
[29]鞠建華,馬俊英,張云,李青連,黃洪波,宋永相,王博,謝運昌. 環(huán)酯肽類抗生素黑莫他丁的高產(chǎn)菌株及其構(gòu)建方法[P]. 廣東省：CN104164399B,2019-06-11.
[30]李文均,劉晴,陳微,高銳,段焰青,侯偉,鞠建華. 一株擬無枝菌酸菌及利用該菌制備特戊依羅霉素的方法[P]. 廣東�。篊N105886421B,2019-04-02.
[31]鞠建華,李青連,秦湘靜,劉靜. 氨基轉(zhuǎn)移酶和異構(gòu)酶在催化形成L-allo-Ile中的應(yīng)用[P]. 廣東�。篊N105154487B,2019-03-05. 國際授權(quán)專利(日本)PCT/CN2015/097205（日本專利：6565839）
[32]鞠建華,宋永相,許芳. 一類環(huán)六肽化合物及其在制備抗良性前列腺增生藥物中的應(yīng)用[P]. 廣東省：CN105294842B,2018-10-02.
[33]鞠建華,朱清華,黃洪波,宋永相,馬俊英,李青連. 一類核苷類抗生素及其在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N105061537B,2018-02-02.
[34]鞠建華,宋永相,李潔,黃洪波. 一類角環(huán)素化合物及其在制備抗腫瘤或抗菌藥物中的應(yīng)用[P]. 廣東省：CN104744533B,2017-08-25.
[35]鞠建華,張幸,桂春. 一種海洋鏈霉菌及其應(yīng)用[P]. 廣東�。篊N104630116B,2017-06-23.
[36]張幸,羅明和,鞠建華. 一種吲哚-3-甲醛類化合物的制備方法和應(yīng)用[P]. 廣東�。篊N104402792B,2017-03-22.
[37]張偲,田新朋,鞠建華,羅明和,尹浩. 一種海洋鏈霉菌及利用其制備Enterocin的方法以及該菌的應(yīng)用[P]. 廣東�。篊N104087523B,2016-09-14.
[38]鞠建華,宋永相,黃洪波,張云. 一類吩嗪化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N103360329B,2015-11-18.
[39]張長生,肖毅,李蘇梅,牛四文,張光濤,張海波,胡濤,鞠建華. 臺勾霉素的生物合成基因簇及其應(yīng)用[P]. 廣東�。篊N102115757B,2015-10-28.
[40]鞠建華,陳奇,紀(jì)昌濤. 一種海洋咔啉生物堿的生物合成基因簇及其應(yīng)用[P]. 廣東�。篊N103275976B,2015-04-08.
[41]鞠建華,丁杰,宋永相. 一種生物堿類化合物的制備方法及其在制備抑制鈣離子通道藥物中的應(yīng)用[P]. 廣東�。篊N103408503B,2015-03-11.
[42]鞠建華,宋永相,黃洪波,張云. 一類萘醌倍半萜化合物及其在制備抗腫瘤或抗菌藥物中的應(yīng)用[P]. 廣東省：CN103396389B,2015-03-04.
[43]鞠建華,宋永相,黃洪波,張云. 兩個環(huán)六肽化合物及其在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N103396476B,2014-12-31.
[44]鞠建華,張云,黃洪波,劉靜,馬俊英. 一種格瑞克霉素和P-1894B的生物合成基因簇及其應(yīng)用[P]. 廣東�。篊N103215281B,2014-06-25.
[45]鞠建華,謝運昌. 灰綠霉素和綠灰霉素的生物合成基因簇及其應(yīng)用[P]. 廣東省：CN102911957B,2014-06-04.
[46]張長生,李慧賢,張慶波,李蘇梅,朱義廣,張光濤,張海波,田新朋,張偲,鞠建華. 廈霉素A和氧廈霉素的生物合成基因簇及其應(yīng)用[P]. 廣東�。篊N102732534B,2014-05-14.
[47]張長生,張慶波,李蘇梅,田新朋,張文軍,張海波,李惠賢,張偲,鞠建華. 鏈霉菌和吲哚倍半萜類化合物及其制備方法和在制備抗菌抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N102757908B,2014-05-14.
[48]張長生,張海波,李蘇梅,張改云,張光濤,朱義廣,陳瑞東,肖吉,鞠建華. 友菌素的生物合成基因簇及其應(yīng)用[P]. 廣東�。篊N102533813B,2014-04-09.
[49]鞠建華,周瀟,黃洪波. 抗生素Tetrathiazomycin A及其制備方法和在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N102775427B,2014-04-09.
[50]鞠建華,黃洪波,任香梅,宋永相,張長生. 一類角環(huán)素類化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N102492006B,2013-12-25.
[51]張長生,李蘇梅,牛四文,胡濤,張光濤,肖毅,張海波,鞠建華. 六種臺勾霉素類化合物及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N102219815B,2013-12-18.
[52]張長生,李蘇梅,牛四文,田新朋,張海波,張光濤,張偲,鞠建華. 抗生素Lobophorin E和F及其制備方法和在制備抗菌、抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N102321133B,2013-11-13.
[53]鞠建華,朱清華,李軍,馬俊英,田新朋,張長生. 一種核苷類抗生素A201A高產(chǎn)菌株及其構(gòu)建方法[P]. 廣東�。篊N102373171B,2013-08-14.
[54]鞠建華,陳子明,黃洪波,宋永相,張長生. 霉酚酸衍生物A、B、C及其在制備免疫抑制藥物中的應(yīng)用[P]. 廣東�。篊N102391225B,2013-07-31.
[55]張長生,張文軍,田新朋,李蘇梅,張慶波,馬亮,張海波,張偲,鞠建華. 鏈霉菌、抗腫瘤化合物Spiro-Indimycin A-D及其制備方法和應(yīng)用[P]. 廣東�。篊N102643765B,2013-06-19.
[56]張偲,張長生,田新朋,李蘇梅,張文軍,張海波,張光濤,尹浩,鞠建華. 一種假諾卡氏菌及利用其制備Deoxynyboquinone的方法[P]. 廣東�。篊N102296039B,2013-04-24.
[57]張長生,李蘇梅,田新朋,張文軍,張海波,張光濤,張偲,鞠建華. 抗生素Pseudonocardian A和B及其制備方法和在制備抗菌、抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N102351859B,2013-02-27.
[58]張長生,李蘇梅,肖毅,牛四文,鞠建華. 四種臺勾霉素類化合物及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N102030791B,2013-01-23.
[59]鞠建華,姚月良,田新朋,張長生,張偲. 一種海洋鏈霉菌以及利用該菌制備替達霉素A和B的方法[P]. 廣東省：CN102168034B,2012-12-05.
[60]鞠建華,黃洪波,姚月良,田新朋,張長生. β-咔啉生物堿及其在制備抗瘧疾藥物中的應(yīng)用[P]. 廣東�。篊N102250089B,2012-11-14.
[61]張長生,李蘇梅,田新朋,牛四文,鞠建華,張偲. 一種鏈霉菌及利用該菌制備多種抗生素的工藝[P]. 廣東省：CN102168044B,2012-09-05.
[62]鞠建華,周俊勇,黃洪波,馬俊英,王博,汪中文,田新朋,張偲,張長生. 一種海洋鏈霉菌及利用其制備星形孢菌素和K-252d的方法[P]. 廣東�。篊N102181387B,2012-07-18.
[63]張長生,李蘇梅,田新朋,牛四文,張文軍,鞠建華,張偲. 一種鏈霉菌及利用該菌發(fā)酵制備抗霉素類抗生素的工藝[P]. 廣東省：CN101974464B,2012-07-04.
[64]楊峻山,鞠建華,王立為,肖培根. 枇杷葉總?cè)扑峤M分及其在制備抗炎、止咳藥物中的應(yīng)用[P]. 北京市：CN100395258C,2008-06-18.
[65]楊峻山,鞠建華. 一種環(huán)菠蘿蜜烷三萜皂甙新化合物及其在心血管病治療中的應(yīng)用[P]. 北京市：CN1162445C,2004-08-18.
[66]楊峻山,鞠建華. 一種環(huán)菠蘿蜜烷三萜皂甙化合物及其在免疫抑制和腫瘤治療中的應(yīng)用[P]. 北京市：CN1150204C,2004-05-19.
發(fā)表英文論文：
2020：
[155]Ji, Xiaoqi, Tu, Jiajia, Song, Yongxiang, Zhang, Chunyan, Wang, Liyan, Li, Qinglian; Ju, Jianhua*.A Luciferase-Like Monooxygenase and Flavin Reductase Pair AbmE2/AbmZ Catalyzes Baeyer–Villiger Oxidation in Neoabyssomicin Biosynthesis.ACS Catalysis, 2020, 10(4): 2591-2595.
[154]Shao, Mingwei, Sun, Changli, Liu, Xiaoxiao, Wang, Xiaoxue, Li, Wenli, Wei, Xiaoyi, Li, Qinglian; Ju, Jianhua*.Upregulation of a marine fungal biosynthetic gene cluster by an endobacterial symbiont.Communications Biology, 2020, 3(1): 527., https://doi.org/10.1038/s42003-020-01239-y.
[153]Zhang, Chunyan; Zhang, Huaran; Ju, Jianhua*.On-PKS Baeyer-Villiger-Type O-Atom Insertion Catalyzed by Luciferase-Like Monooxygenase OvmO during Olimycin Biosynthesis.Organic Letters, 2020, 22(5): 1780-1784.
[152]Chen, Jiang; Gui, Chun; Wei, Qiuyu; Liu, Jie; Ye, Li; Tian, Xinpeng; Gu, Yu-Cheng; Li, Qinglian; Ju, Jianhua*.Characterization of Tailoring Methyltransferases Involved in K-41A Biosynthesis: Modulating Methylation to Improve K-41A Anti-infective Activity.Organic Letters, 2020, 22(12): 4627-4632.
[151]Ji, Xiaoqi, Dong, Yuliang, Ling, Chunyao, Zhou, Zhenbin, Li, Qinglian; Ju, Jianhua.Elucidation of the Tailoring Steps in Julichrome Biosynthesis by Marine Gastropod Mollusk-Associated Streptomyces sampsonii SCSIO 054.Organic Letters, 2020, 22(17): 6927-6931.
[150]Li, Qinglian*, Ding, Wenjuan, Tu, Jiajia, Chi, Changbiao, Huang, Hongbo, Ji, Xiaoqi, Yao, Ziwei, Ma, Ming; Ju, Jianhua*.Nonspecific Heme-Binding Cyclase, AbmU, Catalyzes [4 + 2] Cycloaddition during Neoabyssomicin Biosynthesis.ACS Omega, 2020, 5(32): 20548-20557.
[149]Sun, Changli; Liu, Zhiyong; Zhu, Xiangcheng; Fan, Zhiying; Huang, Xuanmei; Wu, Qiaoling; Zheng, Xiaohong; Qin, Xiangjing; Zhang, Tianyu; Zhang, Hua; Ju, Jianhua*; Ma, Junying*.Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 Delta ilaR.Journal of Natural Products, 2020, 83(5): 1646-1657.
[148]Yang, Zhijie; Sun, Changli; Liu, Zhiyong; Liu, Qing; Zhang, Tianyu; Ju, Jianhua*; Ma, Junying*.Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units.Journal of Natural Products, 2020, 83(5): 1666-1673.
[147]Zhou, Zhenbin; Wu, Qiaoling; Xie, Qing; Ling, Chunyao; Zhang, Hua; Sun, Changli; Ju, Jianhua*.New Borrelidins from Onchidium sp. Associated Streptomyces olivaceus SCSIO LO13.Chemistry and Biodiversity, 2020, 17(1): e1900560., doi: 10.1002/cbdv.201900560.
[146]Dong, Yuliang; Ding, Wenjuan; Sun, Changli; Ji, Xiaoqi; Ling, Chunyao; Zhou, Zhenbin; Chen, Zhiyun; Chen, Xuehong*; Ju, Jianhua*.Julichrome Monomers from Marine Gastropod Mollusk-Associated Streptomyces and Stereochemical Revision of Julichromes Q(3.5) and Q(3.3).Chemistry and Biodiversity, 2020, 17(4): e2000057.
[145]Ding, W.; Dong, Yu.; Ju, J.;* Li, Q.* The roles of genes associated with regulation, transportation, and macrocyclization in desotamide biosynthesis in Streptomyces scopuliridis SCSIO ZJ46. Appl. Microbiol. Biotechnol. 2020, 104, 2603-2610.
[144]Yang, Z.; He, J.; Wei, X.; Ju, J.; Ma, J.* Exploration and genome mining of natural products from marine Streptomyces. Appl. Microbiol. Biotechnol. 2020, 104, 67-76.
[143]Song, Yongxiang; Yang, Jiafan; Yu, Jianchen; Li, Jie; Yuan, Jie; Wong, Nai-Kei; Ju, Jianhua*.Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities.Journal of Antibiotics, 2020, 73(8): 542-547.
[142]He, J.; Wei, X.; Yang, Z.; Li, Y.; Ju, J.; Ma, J.* Characterization of regulatory and transporter genes in the biosynthesis of anti-tuberculosis ilamycins and production in a heterologous host. Mar Drugs. 2020, 18(4). pii: E216. doi: 10.3390/md18040216.
[141]Zhou, W.; Liang, H.; Qin, X.; Cao, D.; Zhu, X.; Ju, J.; Shen, B.; Duan, Y.;* Huang, Y.* The isolation of pyrroloformamide congeners and characterization of their biosynthetic gene cluster. J. Nat. Prod. 2020, 83, 202-209.
[140]Liu, L.; Li, S.; Sun, R.; Qin, X.; Ju, J.; Zhang, C.; Duan, Y.;* Huang, Y.* Activation and characterization of bohemamine biosynthetic gene cluster from Streptomyces sp. CB02009. Org Lett. 2020, doi: 10.1021/acs.orglett.0c01224.
[139]Yang Z, He J, Wei X, Ju J, Ma J.* Exploration and genome mining of natural products from marine Streptomyces. Appl Microbiol Biotechnol. 2020, 104, 67-76.
[138] Hou, L.; Liu, Z.; Yu, D.; Li, H.; Ju, J.; Li, W.* Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66. Bioorg. Chem. 2020, doi: 10.1016/j.bioorg.2020.103954.
[137]Kumar, P. S.; Ling, C. Y.; Zhou, Z. B.; Dong, Y. L.; Sun, C. L.; Song, Y. X.; Wong, N. K.; Ju, J. H.*.Chemical Diversity of Metabolites and Antibacterial Potential of Actinomycetes Associated with Marine Invertebrates from Intertidal Regions of Daya Bay and Nansha Islands.Microbiology, 2020, 89(4): 483-492.
[136]Wang, L.; Li, M.; Lin, Y.; Du, S.; Liu, Z.; Ju, J.; Suzuki, H.; Sawada, M.; Umezawa, K.* Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin. J. Antibiot (Tokyo). 2020, doi: 10.1038/s41429-020-0302-9
[135]Yao, Y.; Sun, S.; Cao, M.; Mao, M.; He, J.; Gai, Q.; Qin, Y.; Yao, X.; Lu, H.; Chen, F.; Wang, W.; Luo, M.; Zhang, H.; Huang, H.; Ju, J.; Bian, X.W.,* Wang, Y.* Grincamycin B functions as a potent inhibitor for glioblastoma stem cell via targeting RHOA and PI3K/AKT. ACS Chem. Neurosci. 2020, doi: 10.1021/acschemneuro.0c00206.
[134]Wang, Z.; Li, ZX.; Zhao, WC.; Huang, HB.; Wang, JQ.; Zhang, H.; Lu, JY.; Wang, RN.; Li, W.; Cheng, Z.; Xu, WL.; Zhu, D.; Zhou, LS.; Jiang, W.; Yu, L.; Liu, JY.; Luo, C.; Zhu, H.; Dan, Ye.; Pan, WJ.; Ju, JH.; Dang, YJ.* Identification and characterization of isocitrate dehydrogenase 1(IDH1) as a functional target of marine natural product grincamycin B. Acta. Pharmacol. Sin. 2020, doi: 10.1038/s41401-020-0491-6.
[133]Zhang, Shanwen; Gui, Chun; Shao, Mingwei; Kumar, Pachaiyappan Saravana; Huang, Hongbo*; Ju, Jianhua*.Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077.Natural Product Research, 2020, 34(11): 1499-1504.
2019年：
[132]Gui, Chun; Chen, Jiang; Xie, Qing; Mo, Xuhua; Zhang, Shanwen; Zhang, Hua; Ma, Junying; Li, Qinglian; Gu, Yu-Cheng; Ju, Jianhua*.CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces.COMMUNICATIONS BIOLOGY, 2019, 2: 454.
[131]Liu, Qing; Liu, Zhiyong; Sun, Changli; Shao, Mingwei; Ma, Junying; Wei, Xiaoyi; Zhang, Tianyu*; Li, Wenjun*; Ju, Jianhua*.Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain.Organic Letters, 2019, 21(8): 2634-2638.
[130]Sun, Changli; Yang, Zhijie; Zhang, Chunyan; Liu, Zhiyong; He, Jianqiao; Liu, Qing; Zhang, Tianyu; Ju, Jianhua*; Ma, Junying*.Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster.Organic Letters, 2019, 21(5): 1453-1457.
[129]Xie, Qing; Yang, Zhijie; Huang, Xuanmei; Zhang, Zikang; Li, Jiangbin; Ju, Jianhua*; Zhang, Hua*; Ma, Junying*.Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway.Journal of Hematology & Oncology, 2019, 12(1): 60.. doi:10.1186/s13045-019-0744-3.
[128]Zhang, Shanwen; Xie, Qing; Sun, Changli; Tian, Xin-Peng; Gui, Chun; Qin, Xiangjing; Zhang, Hua*; Ju, Jianhua*.Cytotoxic Kendomycins Containing the Carbacylic Ansa Scaffold from the Marine-Derived Verrucosispora sp. SCSIO 07399.Journal of Natural Products, 2019, 82(12): 3366-3371..
[127]Luo, Minghe; Zang, Ruochen; Wang, Xin; Chen, Ziming; Song, Xiaoxian; Ju, Jianhua*; Huang, Hongbo*.Natural Hydroxamate-Containing Siderophore Acremonpeptides A-D and an Aluminum Complex of Acremonpeptide D from the Marine-Derived Acremonium persicinum SCSIO 115.Journal of Natural Products, 2019, 82(9): 2594-2600.
[126]Zhu, Qinghua; Song, Yongxiang; Huang, Hongbo; Li, Qinglian*; Ju, Jianhua*.Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs.Organic and Biomolecular Chemistry, 2019, 17(15): 3760-3764.
[125]Pan, Huaqi; Tian, Xinpeng; Shao, Mingwei; Xie, Yunchang; Huang, Hongbo; Hu, Jiangchun; Ju, Jianhua*Genome mining and metabolic profiling illuminate the chemistry driving diverse biological activities of Bacillus siamensis SCSIO 05746.Applied Microbiology and Biotechnology, 2019, 103(10): 4153-4165.
[124]Shao, Mingwei; Ma, Juying; Li, Qinglian; Ju, Jianhua*.Identification of the Anti-Infective Aborycin Biosynthetic Gene Cluster from Deep-Sea-Derived Streptomyces sp. SCSIO ZS0098 Enables Production in a Heterologous Host.Marine Drugs, 2019, 17(2): 127.
[123]Liu, Mengchan; Jia, Yanxi; Xie, Yunchang; Zhang, Chunyan; Ma, Junying; Sun, Changli; Ju, Jianhua*.Identification of the Actinomycin D Biosynthetic Pathway from Marine-Derived Streptomyces costaricanus SCSIO ZS0073.Marine Drugs, 2019, 17(4): 240.doi:10.3390/md17040240.
[122]Zhang, Chunyan; Ding, Wenjuan; Qin, Xiangjing; Ju, Jianhua*.Genome Sequencing of Streptomyces olivaceus SCSIO T05 and Activated Production of Lobophorin CR4 via Metabolic Engineering and Genome Mining.Marine Drugs, 2019, 17(10): 593.. doi: 10.3390/md17100593.
[121]Yang, Z.; Wei, X.; He, J.; Ju, J.;* and Ma, J.* Characterization of the noncanonical regulatory and transporter genes in atratumycin biosynthesis and production in a heterologous host. Marine Drugs. 2019, 17(10). pii: E560. doi: 10.3390/md17100560.
[120]Xie, Y.; Li, Q.; Qin, X.; Ju, J. ;* Ma, J.* Enhancement of himastatin bioproduction via inactivation of atypical repressors in Streptomyces hygroscopicus. Metab. Eng. Commun., 2019, 8:e00084; https://doi.org/10.1016/j.mec.2018.e00084.
[119]Huang, Hongbo; Song, Yongxiang; Zang, Ruochen; Wang, Xin; Ju, Jianhua*.Octyl substituted butenolides from marine-derived Streptomyces koyangensis. Natural Product Research.. 2019 Nov 6:1-6. doi: 10.1080/14786419.2019.1686368.
[118]Zhou, W.; Fang, H.; Wu, Q.; Wang, X.; Liu R.; Li, F.; Xiao, J.; Yuan, L.; Zhou, Z.; Ma, J.; Wang, L.; Zhao, W.; You, H.; Ju, J.; Feng, J.;* Chen, C.* Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2. Int. J. Biol. Sci. 2019, 15(8), 1723-1732.
[117] Meng, L.; Sun, C.; Zhang, C.; Song, S.; Sun, X.; Ju, J.; Deng Y.* Efficacy of compounds isolated from Streptomyces olivaceus against the morphogenesis and virulence of Candida albicans. Mar Drugs. 2019, 17(8), pii: E442.
[116]Jiang, L.; Pu, H.; Qin, X.; Liu, J.; Wen, Z.; Huang, Y.; Xiang, J.; Xiang, Y.; Ju, J.; Duan, Y.;* Huang, Y.* Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001. Nat Prod Res. 2019, 1-8. doi: 10.1080/14786419.2019.1611812.
2018年：
[115]Zhang Chunyan; Yang Zhijie; Qin Xiangjing; Ma Junying; Sun Changli; Huang Hongbo; Li Qinglian; Ju Jianhua*.Genome mining for mycemycin: discovery and elucidation of related methylation and chlorination biosynthetic chemistries.Organic Letters, 2018, 20., 7633–7636.
[114]Li Qinglian+*; Ding Wenjuan; Yao Ziwei; Tu Jiajia; Wang Liyan; Huang Hongbo; Li Shengying; Ju jianhua*.AbmV catalyzes tandem ether installation and hydroxylation during neoabyssomicin/abyssomicin biosynthesis.organic letters, 2018, 20(16): 4854-4857.
[113]Qin, Xiangjing; Xie, Yunchang; Huang, Hongbo; Chen, Qi; Ma, Junying; Li, Qinglian; Ju, Jianhua*.Enzymatic Synthesis of GDP-alpha-L-fucofuranose by MtdL and Hyg20.Organic Letters, 2018, 20(4): 1015-1018.
[112]Huang Hongbo; Song Yongxiang; Li Xin; Wang, Xin; Ling Chunyao; Qin Xiangjing; Zhou Zhenbin; Li Qinglian; Wei Xiaoyi; Ju jianhua*.Abyssomicin monomers and dimers from the marine-derived Streptomyces koyangensis SCSIO 5802.Journal of natural products, 2018, 81(8): 1892-1898..
[111]Zhang Chunyan; Sun Changli; Gui Chun; Wang Liyan; Huang Hongbo; Li Qinglian; ju jianhua*.Biosynthetic Baeyer–Villiger chemistry enables access to two anthracene scaffolds from a single gene cluster in deep sea-derived Streptomyces olivaceus SCSIO T05..Journal of natural products, 2018, 81(7): 1570-1577..
[110]Gui, Chun; Yuan, Jie; Mo, Xuhua; Huang, Hongbo; Zhang, Shanwen; Gu, Yu Cheng; Ju, Jianhua*.Cytotoxic Anthracycline Metabolites from a Recombinant Streptomyces.Journal of Natural Products, 2018, 81(5): 1278-1289.
[109]Sun Changli; Zhang Chunyan; Qin Xiangjing; Wei Xiaoyi; Liu Qing; Li Qinglian; Ju jianhua*.Genome mining of Streptomyces olivaceus SCSIO T05: discovery of olimycins A and B and assignment of absolute configurations.Tetrahedron, 2018. 74, 199-203.
[108]Sun, Jianbin; Shao, Junli; Sun, Changli; Song, Yongxiang; Li, Qinglian; Lu, Laichun; Hu, Yunfeng; Gui, Chun; Zhang, Hua*; Ju, Jianhua*.Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.Bioorganic & Medicinal Chemistry, 2018, 26(8): 1488-1494.
[107]Li Yan; Zhang Chunyan; Liu Chengxiong; Ju Jianhua*; Ma Junying.Genome sequencing of Streptomyces atratus SCSIO ZH16 and activation production of nocardamine via metabolic engineering. Frontiers in Micrbiology, 2018, 9: 1269., doi:10.3389/fmicb.2018.01269
[106]Gui, Chun; Liu, Yena; Zhou, Zhenbin; Zhang, Shanwen; Hu, Yunfeng; Gu, Yu Cheng; Huang, Hongbo*; Ju, Jianhua*.Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp SCSIO GJ056.Marine Drugs, 2018, 16(6): 185.; doi:10.3390/md16060185
[105]Tu, J.; Li, S.; Chen, J.; Song, Y.; Fu, S.; Ju, J.; Li, Q.* Characterization and heterologous expression of the gene cluster for neoabyssomincins and abyssomincins biosynthesis from Streptomyces koyangensis SCSIO 5802. Microb. Cell Fact. 2018, 17(1):28. doi: 10.1186/s12934-018-0875-1
[104]Zhang, S.; Gui, C.; Shao, M.; Kumar, S.; Huang, H.;* Ju, J.* Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077. Nat. Prod. Res. 2018, doi:10.1080/14786419.2018.1493736
[103]Guo, Z.; Li, P.; Chen, G.; Li, C.; Cao, Z.; Zhang, Y.; Ren, J.; Xiang, H.; Lin, S.; Ju, J.; Chen, Y.* Design and biosynthesis of dimeric alboflavusins with biaryl linkages via regiospecific C–C bond coupling. J. Am. Chem. Soc., 2018, 140, 18009–18015.
[102]Deng, Y.; Kang, D.; Qiu, L.; Shi, J.; Zhou,W.; Sun, A.; Ju, J.; Zhu, X.; Shen, B.;* Duan, Y.;* Huang, Y.* The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. MedChemComm. 2018, 9, 789-794.
[101]Hou, L.; Huang, H.; Li, H.; Wang, S.; Ju, J.; Li, W.* Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity. Microb. Cell Fact. 2018, 17(1):61 (doi: 10.1186/s12934-018-0908-9).
[100]Lai, Z.; Yu, J.; Ling, H.; Song, Y.; Yuan, J.; Ju, J.; Tao, Y.;* Huang, H.* Grincamycins I - K, cytotoxic angucycline glycosides derived from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. Planta Med. 2018, 84, 201-207.
2017年：
[99]Zhu, Qinghua; Chen, Qi; Song, Yongxiang; Huang, Hongbo; Li, Jun; Ma, Junying; Li, Qinglian; Ju, Jianhua*.Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-L-galactose mutase.Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(19): 4948-4953.
[98]Ma, Junying*; Huang, Hongbo; Xie, Yunchang; Liu, Zhiyong; Zhao, Jin; Zhang, Chunyan; Jia, Yanxi; Zhang, Yun; Zhang, Hua; Zhang, Tianyu; Ju, Jianhua*.Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents.Nature Communications, 2017, 8(1): 391.(doi: 10.1038/s41467-017-00419-5).
[97]Gui, Chun; Mo, Xuhua; Gu, Yu Cheng; Ju, Jianhua*.Elucidating the Sugar Tailoring Steps in the Cytorhodin Biosynthetic Pathway.Organic Letters, 2017, 19(20): 5617-5620.
[96]Gui Chun; Zhang Shanwen; Zhu Xiangcheng; Ding Wenjuan; Huang Hongbo; Gu Yu Cheng; Duan Yanwen; Ju Jianhua*.Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.Journal of Natural Products, 2017, 80(5): 1594-1603.
[95]Luo, Minghe; Cuo, Zhaomeng; Huang, Hongbo; Song, Xianqin; Sun, Aijun; Dang, Yongjun; Lu, Laichun*; Ju, Jianhua*.Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp SCSIO sof101.Journal of Natural Products, 2017, 80(5): 1668-1673.
[94]Xie Yunchang; Ma Junying; Qin Xiangjing; Li Qinglian; Ju Jianhua*.Identification and utilization of two important transporters: SgvT1 and SgvT2, for griseoviridin and viridogrisein biosynthesis in Streptomyces griseoviridis.Microbial Cell Factories, 2017, 16(1): 177. (doi:10.1186/s12934-017-0792-8).
[93]Song, Yongxiang; Li, Qinglian; Qin, Fengxiang; Sun, Changli; Liang, Hao; Wei, Xiaoyi; Wong, Nai Kei; Ye, Li; Zhang, Yun; Shao, Mingwei; Ju, Jianhua*.Neoabyssomicins A-C, polycyclic macrolactones from the deep-sea derived Streptomyces koyangensis SCSIO 5802.Tetrahedron, 2017, 73(36): 5366-5372.
[92]Chen, Erquan; Chen, Qi; Chen, Shaoming; Xu, Bing; Ju, Jianhua*; Wang, Huan*.Mathermycin, a Lantibiotic from the Marine Actinomycete Marinactinospora thermotolerans SCSIO 00652.Applied and Environmental Microbiology, 2017, 83(15): UNSP e00926-17. (doi: 10.1128/AEM.00926-17).
[91] Li, H.; Huang, H.; Hou, L.; Ju, J.; Li, W.* Discovery of antimycin-type depsipeptides from a wbl gene mutant strain of deep sea-derived Streptomyces somaliensis SCSIO ZH66 and their effects on pro-inflammatory cytokine production. Front Microbiol. 2017, 8, 678.
[90]Zhu, X.; Duan, Y.; Cui, Z.; Wang, Z.; Li, Z.; Zhang, Y.; Ju, J.; Huang, H.* Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32. J. Antibiot. 2017, 70, 819-822.
[89]Mo, X.*; Shi, C.; Gui, C.; Zhang, Y.; Ju, J.; Wang, Q.* Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster. Microb. Cell Fact. 2017, 16(1):100.
[88]Lai, Z.; Yu, J.; Ling, H.; Song, Y.; Yuan, J.; Ju, J.; Tao, Y.;* Huang, H.* Grincamycins I - K, cytotoxic angucycline glycosides derived from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. Planta Med. 2017, doi: 10.1055/s-0043-119888.
[87] Li, X.; Xia, Z.; Tang, J.; Wu, J.; Tong, J.; Li, M.; Ju, J.; Chen, H.; Wang, L.* Identification and biological evaluation of secondary metabolites from marine derived fungi-Aspergillus sp. SCSIOW3, cultivated in the presence of epigenetic modifying agents. Molecules, 2017, 22(8), pii: E1302 (doi: 10.3390/molecules22081302).
[86]Wang, Yi Huan; Salam, Nimaichand; Liu, Qing; Yang, Zi Wen; Cao, Li Xiang; Meng, Xiao Lin; Nie, Guo Xing; Ju, Jian Hua*; Li, Wen Jun*.Symbiotic bacteria associated with puffer fish Gastrophysus spadiceus and evaluation of their antimicrobial activities.3 Biotech, 2017, 7(6): 366.
2016年：
[85]Li, Qinglian; Qin, Xiangjing; Liu, Jing; Gui, Chun; Wang, Bo; Li, Jie; Ju, Jianhua*.Deciphering the Biosynthetic Origin of l-allo-Isoleucine..Journal of the American Chemical Society, 2016, 138(1): 408-415. (Highlighted in JACS Spotlights, 2016, 138, 461; Hot off the Press in Natural Products Reports, 2016, 33, 530).
[84]Luo, M.; Tang, G.; Ju, J.; Lu, L.; Huang, H.* A new diketopiperazine derivative from a deep sea-derived Streptomyces sp. SCSIO 04496. Nat. Prod. Res. 2016, 30, 138-143.
[83]Huang, H.; Li, H.; Qiu, Y.; Hou, L.; Ju, J.; Li, W.* A new dioic acid from a wbl gene mutant of deep sea-derived Streptomyces somaliensis SCSIO ZH66. Mar Drugs. 2016, 14(10). pii: E184.
[82]Huang, H.; Hou, L.; Li, H.; Qiu, Y.; Ju, J.; Li, W.* Activation of a plasmid-situated type III PKS gene cluster by deletion of a wbl gene in deepsea-derived Streptomyces somaliensis SCSIO ZH66. Microb. Cell Fact. 2016, 15(1):116.
2015年：
[81]Liu, Jing#; Wang, Bo#; Li, Hongzhi; Xie, Yunchang; Li, Qinglian; Qin, Xiangjing; Zhang, Xing; Ju, Jianhua*.Biosynthesis of the Anti-infective Marformycins Featuring Pre-NRPS Assembly Line N-Formylation and O-Methylation and Post-Assembly Line C-Hydroxylation Chemistries.Organic Letters, 2015, 17(6): 1509-1512. (Hot off the Press in Natural Product Reports).
[80]Gui, Chun#; Li, qinglian#; Mo, xuhua#; Qin, xiangjing; Ma, junying; Ju, jianhua*.Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis.Oganic Letter, 2015, 17(3): 628-631.
[79]Li, Qinglian; Song, Yongxiang; Qin, Xiangjing; Zhang, Xing; Sun, Aijun; Ju, Jianhua*.Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host.Journal of Natural Products, 2015, 78(4): 944-948.
[78]Song, Yongxiang#; Liu, Guangfu#; Li, jie; Huang, hongbo; Zhang, xing; Zhang, Hua*; Ju, jianhua*.Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594.Marine Drugs, 2015, 13(3): 1304-1316.
[77]Medema, M.H.; et al; Xie, Y.; et al; Ju, J.; et al, Glöckner, F.O.* Minimum Information about a Biosynthetic Gene cluster. Nat. Chem. Biol. 2015, 11, 625-631.
[76]Huang, Sheng-Xiong; Yun, Bong-Sik; Ma, Ming; Basu, Hirak S; Church, Dawn R; Ingenhorst, Gudrun; Huang, Yong; Yang, Dong; Lohman, Jeremy R; Tang, Gong-Li; Ju, Jianhua; Liu, Tao; Wilding, George; Shen, Ben*.Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species.Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(27): 8278-8283.
[75]Zhang, Yonghe; Huang, Huiming; Xu, Shanshan; Wang, Bo; Ju, Jianhua; Tan, Huarong; Li, Wenli*.Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology.Microbial Cell Factories, 2015, 14(64): 64.
2014年：
[74]Song, Yongxiang; Li, Qinglian; Liu, Xue; Chen, Yuchan; Zhang, Yun; Sun, Aijun; Zhang, Weimin; Zhang, Jingren; Ju, Jianhua*.Cyclic hexapeptides from the deep South China Sea-derived Streptomyces scopuliridis SCSIO ZJ46 ative against pathogenic gram-positive bacteria.Journal of Natural Products, 2014, 77(8): 1937-1941.
[73]Xie, Yunchang; Li, Qinglian; Song, Yongxiang; Ma, Junying; Ju, Jianhua*.Involvement of SgvP in carbon-sulfur bond formation during griseoviridin biosynthesis.ChemBioChem, 2014, 15(8): 1183-1189. (commented by Faculty of 1000).
[72]Ji, Changtao; Chen, Qi; Li, Qinglian; Huang, Hongbo; Song, Yongxiang; Ma, Junying; Ju, Jianhua*.Chemoenzymatic synthesis of β-carboline derivatives using McbA, a new ATP-dependent amide synthetase.Tetrahedron Letters, 2014, 55(35): 4901-4904.
[71]Mo, Xuhua; Li, Qinglian; Ju, Jianhua*.Naturally occurring tetramic acid products: isolation, structure elucidation and biological activity.RSC Advances, 2014, 4(92): 50566-50593..
[70]Zhou, Xiao#; Huang, Hongbo#; Li, Jie; Song, Yongxiang; Jiang, Rengwang; Liu, Jing; Zhang, Si; Hua, Yan*; Ju, Jianhua*.New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141.Tetrahedron, 2014, 70(42): 7795-7801.
[69]Seo, J.W.; Ma, M.; Kwong, T.; Ju, J.; Lim, S.K.; Jiang, H.; Lohman, J.R.; Yang, C.; Cleveland, J.; Zazopoulos, E.; Farnet, C.M.; Shen, B.* Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. Biochemistry. 2014, 53(49):7854-7865.
[68]Wang, H.; Zhang, H.; Mi, Y.; Ju, J.; Chen, Q.; Zhang, H.* Expression, crystallization and preliminary X-ray analysis of McbB, a multifunctional enzyme involved in β-carboline skeleton biosynthesis. Acta Crystallogr F Struct Biol Commun. 2014, 70(Pt 10), 1402-145.
2013年：
[67]Chen, Qi; Ji, Changtao; Song, Yongxiang; Huang, Hongbo; Ma, Junying; Tian, Xinpeng; Ju, Jianhua*. Discovery of McbB, a novel enzyme catalyzing the β-Carboline skeleton construction in the marinacarboline biosynthetic pathway. Angewandte Chemie International Edition, 2013, 52(38): 9980-9984. (commented by Faculty of 1000).
[66]Zhang, Yun#; Huang, Hongbo#; Chen, Qi; Luo, Minghe; Sun, Aijun; Song, Yongxiang; Ma, Junying; Ju, Jianhua*.Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety. Organic Letters, 2013, 15(13): 3254-3257.
[65] Wang, Bo#; Song, Yongxiang#; Luo, Minghe; Chen, Qi; Ma, Junying; Huang, Hongbo; Ju, Jianhua*. Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation. Organic Letters, 2013, 15(6): 1278-1281.
[64]Song, Yongxiang; Huang, Hongbo; Chen, Yuchan; Ding, Jie; Zhang, Yun; Sun, Aijun; Zhang, Weimin; Ju, Jianhua*.Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. Journal of Natural Products, 2013, 76(12): 2263-2268.
[63]Zhang, Yun; Zhou, Xiao; Huang, Hongbo; Tian, Xinpeng; Song, Yongxiang; Zhang, Si; Ju, Jianhua*. 03219A, a new Δ8,9-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment. Jounary of Antibiotics (Tokyo), 2013, 66(6): 327-331.
[62]Zhang, Huaidong; Chen, Jie; Wang, Hua; Xie, Yunchang; Ju, Jianhua; Yan, Yunjun*; Zhang, Houjin*. Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis. FEBS Letters, 2013, 587(11): 1675-1680.
[61]Ma Ming; Kwong Thomas; Lim Si-Kyu; Ju Jianhua; Lohman Jeremy R; Shen Ben*. Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity. Journal of the American Chemical Society, 2013, 135(7): 2489-2492.
2012年：
[60]Mo, Xuhua; Ma, Junying; Huang, Hongbo; Wang, Bo; Song, Yongxiang; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*.Delta(11,12) double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme. Journal of the American Chemical Society, 2012, 134(6): 2844-2847. (highlighted in Nat. Chem. Biol. 2012, 8, 320).
[59]Zhu, Qinghua; Li, Jun; Ma, Junjing; Luo, Minghe; Wang, Bo; Huang, Hongbo; Tian, Xinpeng; Li, Wenjun; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*. Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from deep sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrob. Antimicrobial Agents and Chemotherapy, 2012, 56(1): 110-114.
[58]Xie, Yunchang; Wang, Bo; Liu, Jing; Zhou, Junchao; Ma, Junying; Huang, Hongbo; Ju, Jianhua*.Identification of the biosynthetic gene cluster and regulatory cascade for the synergistic antibacterial antibiotics griseoviridin and viridogrisein in Streptomyces griseoviridis. ChemBioChem, 2012, 13(18): 2745-2757. (highlighted as an an inside cover).
[57]Ma, Junying; Zuo, Dianguang; Song, Yongxiang; Wang, Bo; Huang, Hongbo; Yao, Yueliang; Li, Wenjun; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*. Characterization of a single gene cluster that is responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans. ChemBioChem, 2012, 13(4): 547-552.
[56]Huang, Hongbo; Yang, Tingting; Ren, Xiangmei; Liu, Jing; Song, Yongxiang; Sun, Aijun; Ma, Junying; Wang, Bo; Zhang, Yun; Huang, Caiguo; Zhang, Changsheng; Ju, Jianhua*.Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32. Journal of Natural Products, 2012, 75(2): 202-208.
[55]Chen, Ziming; Song, Yongxiang; Chen, Yuchan; Huang, Hongbo; Zhang, Weimin; Ju, Jianhua*.Cyclic heptapeptides, cordyheptapeptides C-E, from the marine-derived fungus Acremonium persicinum SCSIO 115 and their cytotoxic activities.Journal of Natural Products, 2012, 75(6): 1215-1219.
[54]Huang, Hongbo#; Wang, Fazuo#; Luo, Minghe#; Chen, Yuchan; Song, Yongxiang; Zhang, Weimin; Zhang, Si; Ju, Jianhua*.Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063.Journal of Natural Products, 2012, 75(7): 1346-1352.
[53]Zhou, Xiao#; Huang, Hongbo#; Chen, Yuchan; Tan, Jiaheng; Song, Yongxiang; Zou, Jianhua; Tian, Xinpeng; Hua, Yan*; Ju, Jianhua*.Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.Journal of Natural Products, 2012, 75(12): 2251-2255.
[52]Chen, Ziming; Zheng, Zhihui; Huang, Hongbo; Song, Yongxiang; Zhang, Xuelian; Ma, Junying; Wang, Bo; Zhang, Changsheng; Ju, Jianhua*.Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07.Bioorganic & Medicinal Chemistry Letters, 2012, 22(9): 3332-3335.
[51]Zhang, W.; Liu, Z.; Li, S.; Yang, T.; Zhang, Q.; Ma, L.; Tian, X.; Zhang, H.; Huang, C.; Zhang, S.; Ju, J; Shen, Y.; Zhang, C.*Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete..Org Lett, 2012, 14(13): 3364-3367.
[50]Zhu, Y.; Fu, P.; Lin, Q.; Zhang, G.; Zhang, H.; Li, S.; Ju, J.; Zhu, W.; Zhang, C.*Identification of caerulomycin A gene cluster implicates a tailoring amidohydrolase..Org Lett, 2012, 14(11): 2666-2669.
[49]Li Huixian#; Zhang Qingbo#; Li Shumei; Zhu Yiguang; Zhang Guangtao; Zhang Haibo; Tian Xinpeng; Zhang Si; Ju Jianhua; Zhang Changsheng*.Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis.Journal of the American Chemical Society, 2012, 134(21): 8996-9005.
2011年：
[48]Ma, Junying; Wang, Zhongwen; Huang, Hongbo; Luo, Minghe; Zuo, Dianguang; Wang, Bo; Sun, Aijun; Cheng, Yiqiang; Zhang, Changsheng; Ju, Jianhua*.Biosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps. Angewandte Chemie International Edition, 2011, 50(34): 7797-7802.(commented by Faculty of 1000).
[47]Mo, Xuhua; Huang, Hongbo; Ma, Junying; Wang, Zhongwen; Wang, Bo; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*.Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway.Organic Letters, 2011, 13(9): 2212-2215.
[46]Huang, Hongbo#; Yao, Yueliang#; He, Zhengxiang; Yang, Tingting; Ma, Junying; Tian, Xinpeng; Li, Yayong; Huang, Caiguo; Chen, Xiaoping; Li, Wenjun; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*.Antimalarial beta-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.Journal of Natural Products, 2011, 74(10): 2122-2127. (highlighted by Global Medical Discovery).
[45]Mo, Xuhua; Wang, Zhongwen; Wang, Bo; Ma, Junying; Huang, Hongbo; Tian, Xinpeng; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*.Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived treptomyces sp. SCSIO1666.Biochemical and Biophysical Research Communications, 2011, 406(3): 341-347.
[44]Chen, Ziming; Huang, Hongbo; Chen, Yuchan; Wang, Zhongwen; Ma, Junying; Wang, Bo; Zhang, Weimin; Zhang, Changsheng; Ju, Jianhua*. New cytochalasins from the marine-derived fungus xylaria sp. SCSIO 156.Helvetica Chimica Acta, 2011, 94(9): 1671-1676.
[43]Huang, Y.; Huang, S-X.; Ju, J.; Tang, G.; Liu, T.; Shen, B.*.Characterization of the InmKLM Genes Unveiling Key Intermediates for beta-Alkylation in Leinamycin Biosynthesis.Organic Letters, 2011, 13(3): 498-501.
[42]Xiao Yi; Li Shumei; Niu Siwen; Ma Liang; Zhang Guangtao; Zhang Haibo; Zhang Gaiyun; Ju Jianhua; Zhang Changsheng*.Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase.Journal of the American Chemical Society, 2011, 133(4): 1092-1105.
[41]Ling, J.*; Zhang, G.; Sun, H.; Fan, Y.; Ju. J.; Zhang, C..Isolation and Characterization of a Novel Pyrene-degrading Bacillus vallismortis strain JY3A.Science of the Total Environment, 2011, 409(10): 1994-2000.
[40]Niu, S.; Hu, T.; Li, S.; Xiao, Y.; Ma, L.; Zhang, G.; Zhang, H.; Yang, X.; Ju, J.; Zhang, C.*.Characterization of a Sugar-O-methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Properties and Reveals Substrate Promiscuity.ChemBioChem, 2011, 12(11): 1740-1748.
[39]Huang, H.; Feng, X.; Xiao, Z.; Liu, L.; Li, H.; Ma, L.; Lu ,Y.; Ju, J.; She, Z.*; Lin, Y.*Azaphilones and p-Terphenyls from the Mangrove Endophytic Fungus Penicillium chermesinum (ZH4-E2) Isolated from the South China Sea.Journal of Natural Products, 2011, 74(5): 997-1002.
[38]Niu, S.; Li, S.; Chen, Y.; Tian, X.; Zhang, H.; Zhang, G.; Zhang, W.; Yang, X.; Zhang, S.; Ju, J.; Zhang, C.*Lobophorins E and F, New Spirotetronate Antibiotics from a South China Sea-derived Streptomyces sp SCSIO 01127.Journal of Antibiotics, 2011, 64(11): 711-716.
[37]Li, S.; Tian, X.; Niu, S.; Zhang, W.; Chen, Y.; Zhang, H.; Yang, X.; Zhang, W.; Li ,W.; Zhang, S.; Ju, J.; Zhang, C.*.Pseudonocardians A-C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp SCSIO 01299.Marine Drugs, 2011, 9(8): 1428-1439.
[36]Huang, H.; Xiao, Z.; Feng, X.; Huang, C.; Zhu, X.; Ju, J.; Li, M.; Lin, Y.; Liu, L.*; She, Zh.*.Cytotoxic Naphtho-γ-pyrones from the Mangrove Endophytic Fungus Aspergillus tubingensis (GX1-5E).Helvetical Chimica Acta, 2011, 94(9): 1732-1740.
Other representative publications：
[35]Schneider-Poetsch Tilman.; Ju Jianhua; Eyler Daniel E; Dang Yongjun; Bhat Shridhar; Merrick William C; Green Rachel; Shen Ben; Liu Jun O*.Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.Nature Chemical Biology, 2010, 6(3): 209-217.
[34]Luo Yinggang; Li Wenli; Ju Jianhua; Yuan Qiuping; Peters Noel R; Hoffmann F Michael; Huang Shengxiong; Bugni Tim S; Rajski Scott; Osada Hiroyuki; Shen Ben*.Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.Journal of the American Chemical Society, 2010, 132(19): 6663-6671.
[33]Zhao, C.; Coughlin, J.; Ju, J.; Zhu, D.; Wendt-Pienkowski, E.; Zhou, X.; Wang, Z.; Shen, B.*; Deng, Z.*Oxazolomycin Biosynthesis in Streptomyces albus JA3453 Featuring an "Acyltransferase-less" Type I Polyketide Synthase That Incorporates Two Distinct Extender Units.Journal of Biological Chemistry, 2010, 285(26): 20097-20108.
[32]Chen, Y.; Wendt-Pienkowski, E.; Ju, J.; Lin, S.; Rajski, S.; Shen, B.*Characterization of FdmV as an Amide Synthetase for Fredericamycin A Biosynthesis in Streptomyces griseus ATCC 43944.Journal of Biological Chemistry., 2010, 285(50): 38853-38860.
[31]Ju, J.; Rajski, S.; Lim, S-K.; Seo, J-W.; Peters, N.; Hoffmann, F.; Shen, B.*Lactimidomycin, Iso-migrastatin and Related Glutarimide-Containing 12-Membered Macrolides Are Extremely Potent Inhibitors of Cell Migration.Journal of the American Chemical Society, 2009, 131(4): 1370-1371.
[30]Ju, J.; Li, W.; Yuan, Q.; Peters, N.; Hoffmann, F.; Rajski, S.; Osada, H.; Shen, B.*.Functional Characterization of ttmM Unveils New Tautomycin Analogs and Insight into Tautomycin Biosynthesis and Activity.Organic Letters, 2009, 11(7): 1639-1642.
[29]Lim, S.; Ju, J.; Zazopoulos, E.; Jiang, H.; Seo, J.; Chen, Y.; Feng, Z.; Rajski, S.; Farnet, C.; Shen, B.*.Iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase.Journal of Biological Chemistry, 2009, 284(43): 29746-29756.
[28]Li, W.; Luo, Y.; Ju, J.; Rajski, S.; Osada, H.; Shen, B.*.Characterization of the Tautomycetin Biosynthetic Gene Cluster from Streptomyces griseochromogenes Provides New Insight into Dialkylmaleic Anhydride Biosynthesis.Journal of Natural Products, 2009, 72(3): 450-459.
[27]Adler, J.T; Cook, M.; Luo, Y.; Pitt, S.; Ju, J.; Li, W.; Shen, B.; Kunnimalaiyaan, M.; Chen, H.*.Tautomycetin and Tautomycin Suppress the Growth of Medullary Thyroid Cancer Cells via Inhibition of Glycogen Synthase Kinase-3 beta.Molecular Cancer Therapeutics, 2009, 8(4): 914-920.
[26]Pinchot, S.; Adler, J.; Luo, Y.; Ju, J.; Li, W.; Shen, B.; Kunnimalaiyaan, M.; Chen, H.*.Tautomycin Suppresses Growth and Neuroendocrine Hormone Markers in Carcinoid Cells through Activation of the Raf-1 Pathway.The American Journal of Surgery, 2009, 197(3): 313-319.
[25]Ju, J.; Rajski, S.; Lim, S-K.; Seo, J-W.; Peters, N.; Hoffmann, F.; Shen, B.*.Evaluation of New Migrastatin and Dorrigocin Congeners Unveils Cell Migration Inhibitors with Dramatically Improved Potency.Bioorganic & Medicinal Chemistry Letters, 2008, 18(22): 5951-5954.
[24]Pinchot, S. N.; Adler, J. T.; Luo, Y.; Ju, J.; Li, W.; Shen, B.; Kunnimalaiyaan, M.; Chen, H*. Tautomycin suppress carcinoid tumor growth and bioactive hormone production through inactivation of the glycogen synthase kinase-3 beta. J. Am. Coll. Surg. 2008, 207, S103-S104.
[23]Song, D.; Coughlin, J.; Ju, J.; Zhou, X.; Shen, B.; Zhao, C.*; Deng, Z.*.Alternative Method for Site-directed Mutagenesis of Complex Polyketide Synthase in Streptomyces albus JA3453.Acta Biochimica et Biophysica Sinica, 2008, 40(4): 319-326.
[22]Zhang, J.; Van Lanen, S.; Ju, J.; Liu, W.; Dorrestein, P.; Li, W.; Kelleher, N.; Shen, B.*.A Phosphopantetheinylating Polyketide Synthase Producing a Linear Polyene to Initiate Enediyne Antitumor Antibiotic Biosynthesis.Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(5): 1460-1465.
[21]Li, W.; Ju, J.; Rajski, S.; Osada, H.; Shen, B.*.Characterization of the Tautomycin Biosynthetic Gene Cluster from Streptomyces Spiroverticillatus Unveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis.Journal of Biological Chemistry, 2008, 283(42): 28607-28617.
[20]Chen, Y.; Luo, Y.; Ju, J.; Wendt-Pienkowski, E.; Rajski, S.; Shen, B.*.Identification of Fredericamycin E from Streptomyces griseus: Insights into Fredericamycin A Biosynthesis Highlighting Carbaspirocycle Formation.Journal of Natural Products, 2008, 71(3): 431-437.
[19]Kennedy, D.; Ju, J.; Shen, B.; Beerman, T.*。Designer Enediynes Generate DNA Breaks, Interstrand Cross-links, or Both, with Concomitant Changes in the Regulation of DNA Damage Responses。Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(45): 17632-17637.
[18]Ju, J.; Seo, J.; Her, Y.; Lim, S-K.; Shen, B.*.New Lactimidomycin Congeners Shed Insight into Lactimidomycin Biosynthesis in Streptomyces amphibiosporus.Organic Letters, 2007, 9(25): 5183-5186.
[17]Guan, C.; Ju, J.; Borlee ,B.; Williamson, L.; Shen, B.; Raffa, K.; Handelsman, J.*.Signal Mimics Derived from a Metagenomic Analysis of the Gypsy Moth Gut Microbiota.Applied and Environment Microbiology, 2007, 73(11): 3669-3676.
[16]Kennedy, D.; Gawron, L.; Ju, J.; Liu, W.; Shen, B.; Beerman, T.*.Single Chemical Modifications of the C-1027 Enediyne Core, a Radiomimetic Antitumor Drug, Affect both Drug Potency and the Role of Ataxia-telangiectasia Mutated in Cellular Responses to DNA Double-strand Breaks.Cancer Research, 2007, 67(2): 773-781.
[15]Ju, J.; Lim, S-K.; Jiang, H.; Seo, J-W.; Her, Y.; Shen, B.*.Thermolysis of Isomigrastatin and its Congeners via [3,3]-sigmatropic Rearrangement: A New Route to the Synthesis of Migrastatin and its Analogues.Organic Letters, 2006, 8(25): 5865-5868.
[14]Li, W.; Ju, J.; Osada, H.; Shen, B.*.Utilization of The Methoxymalonyl-acyl Carrier Protein Biosynthesis Locus for Cloning of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus.Journal of Bacteriology, 2006, 188(11): 4148-4152.
[13]Zhao, C.; Ju, J.; Christenson, S.; Smith, W.; Song, D.; Zhou, X.; Shen, B.*; Deng, Z.*.Utilization of the Methoxymalonyl-acyl Carrier Protein Biosynthesis Locus for Cloning the Oxazolomycin Biosynthetic Gene Cluster from Streptomyces albus JA3453.Journal of Bacteriology, 2006, 188(11): 4142-4147.
[12]Ju, J.; Lim, S.; Jiang, H.; Seo, J.; Shen, B.*.Iso-migrastatin Congeners from Streptomyces platensis and Generation of a Glutarimide Polyketide Library Featuring the Dorrigocin, Lactimidomycin, Migrastatin, and NK30424 Scaffolds.Journal of the American Chemical Society, 2005, 127(34): 11930-11931.
[11]Ju, J.; Lim, S.; Jiang, H.; Shen, B.*.Migrastatin and Dorrigocins are Shunt Metabolites of iso-migrastatin.Journal of the American Chemical Society, 2005, 127(6): 1622-1623.
[10]Van Lanen, S.; Dorrestein, P.; Christenson, S.; Liu, W.; Ju, J.; Kelleher, N.; Shen, B.*.Biosynthesis of the Beta-amino Acid Moiety of the Enediyne Antitumor Antibiotic C-1027 Featuring beta-amino Acyl-S-carrier Protein Intermediates.Journal of the American Chemical Society, 2005, 127(33): 11594-11595.
[9]M.; Van Lanen, S.; Ju, J.; Thorson, J.; Shen, B.*.Antitumor Antibiotics: Bleomycin, Endiynes, and Mitomycin.Chemical Review Galm, U.; Hager, s, 2005, 105(2): 739-758.
[8]Liu, D.; Ju, J.; Zou, Z.; Lin, G.; Yang, J.*.Isolation and Structure Determination of Cypritiibetquinone A and B, two new Phenanthraquinones from Cypripedium Tibeticum.Acta Pharmaceutica Sinica, 2005, 40(3): 255-257.
[7]Ju, J.; Ozanick, S.; Shen, B.; Thomas, M.*Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the Viomycin Biosynthetic Pathway of Streptomyces sp strain ATCC11861.ChemBioChem, 2004, 5(9): 1281-1285.
[6]Ju, J.; Zhou, L.; Lin, G.; Liu, D.; Wang, L-W.; Yang, J-S.*.Studies on Constituents of Triterpene acids from Eriobotrya japonica and Their Anti-inflammatory and Antitussive Effects.Chinese Pharmaceutical Journal, 2003, 38(10): 752-757.
[5]Ju, J.*; Liu, D.; Lin, G.; Xu, X.; Han, B.; Yang, J.*; Tu, G.; Ma, L..Beesiosides A-F, Six New Cycloartane Triterpene Glycosides from Beesia calthaefolia.Journal of Natural Products, 2002, 65(1): 42-47.
[4]Liu, D.; Ju, J.; Lin, G.; Xu, X.; Yang, J.*; Tu, G. New C-glycosylflavones from Tetrastigma Hemsleyanum (Vitaceae).Acta Botanica Sinica, 2002, 44(2): 227-229.
[3]Ju, J.*; Liu, D.; Lin, G.; Zhang, Y.; Yang, J.*; Lu, Y.; Gong, N; Zhene, Q..Beesiosides G, H, and J-N, Seven New Cycloartane Triterpene Glycosides from Beesia calthifolia.Journal of Natural Products, 2002, 65(2): 147-152.
[2]Ju, J.; Liu, D.; Lin, G.; Xu, X.; Yang, J.*; Tu, G.; Ma, L..New Triterpenic Glucoside from Beesia calthaefolia (Maxim.) Ulbr. native to China.Acta Botanica Sinica, 2001, 43(9): 983-987.
[1]Ju, J.; Yang, J.*; Li, J.; Xiao, P.Cypripediquinone A, a New Phenanthraquinone from Cypripedium macranthum (Orchidaceae).Chinese Chemical Letters, 2000, 11(1): 37-38.
發(fā)表中文期刊論文：
[1]宋永相,李曉悅,鞠建華. 深海放線菌Streptomyces koyangensis SCSIO 5802中次級代謝產(chǎn)物neoabyssomicin H的分離鑒定[J]. 熱帶海洋學(xué)報,2023,42(03):169-173.
[2]吳巧靈,孫長利,周鎮(zhèn)檳,喬伊君,苗宗余,蔡磊,鞠建華. 石磺來源海洋鏈霉菌Streptomyces ardesiacus SCSIO LO23中g(shù)ermicidin類化合物的分離鑒定及其生物合成分析[J]. 微生物學(xué)報,2022,62(07):2594-2609.
[3]姚紫薇,孫長利,李青連,鞠建華. 犬尿氨酸-3-單加氧酶SibC的體外蛋白表達純化與生化反應(yīng)[J]. 中國海洋藥物,2022,41(01):17-23.
[4]梁智鋮,李駿,凌春耀,許潤,譚彬,黃洪波,鞠建華,李青連. 海洋鏈霉菌Streptomyces parvus SCSIO Mla-L010中大環(huán)內(nèi)酰胺類抗生素vicenistatin的糖基定向改造[J]. 中國海洋藥物,2021,40(06):1-12.
[5]鞠建華,楊鎮(zhèn)業(yè),李青連,韓亞楠,李艷青,喬伊君,楊虎,張華然. 微生物藥物研究開發(fā)現(xiàn)狀與思考[J]. 山東大學(xué)學(xué)報(醫(yī)學(xué)版),2021,59(09):43-50+63.
[6]李艷青,凌春耀,易湘茜,高程海,鞠建華,馬俊英. 海鞘來源放線菌Streptomyces pratensis SCSIO LCY05中skyllamycins的發(fā)現(xiàn)及其生物合成分析[J]. 中國海洋藥物,2021,40(03):1-14.
[7]于東琪,侯路寬,李花月,鞠建華,李文利. 深海鏈霉菌Streptomyces somaliensis SCSIO ZH66 ptm生物合成基因簇中orf7功能的探究[J]. 中國海洋藥物,2021,40(03):15-21.
[8]周曉雪,楊佳凡,李明哲,宋永相,鞠建華,李曉帆,王立巖. 珊瑚來源真菌Parengyodontium album SCSIO SX7W11中聚酮化合物的發(fā)現(xiàn)及其生物合成途徑分析[J]. 微生物學(xué)報,2021,61(11):3631-3641.
[9]李駿,周雪峰,潘劍宇,田新朋,鞠建華. 廣東省海洋生物醫(yī)藥產(chǎn)業(yè)現(xiàn)狀與發(fā)展機遇的思考[J]. 中國海洋藥物,2021,40(01):41-48.
[10]凌春耀,黃洪波,高程海,秦湘靜,鞠建華,易湘茜. 海鞘來源放線菌Streptomyces pratensis SCSIO LCY05中anthracimycin類化合物及其抗菌活性研究[J]. 中國海洋藥物,2020,39(03):7-14.
[11]涂佳佳,鞠建華,付少彬,李青連. 海洋放線菌Streptomyces koyangensis SCSIO 5802中多烯大環(huán)內(nèi)酯類抗生素candicidin生物合成基因簇的分析鑒定[J]. 遵義醫(yī)學(xué)院學(xué)報,2019,42(01):35-44.
[12]徐明遠,肖菲,李花月,鞠建華,李文利. 色氨酸分解代謝途徑阻斷對深海鏈霉菌ZH66次級代謝及生長的影響[J]. 中國海洋藥物,2018,37(06):8-14.
[13]張善文,桂春,秦湘靜,田新朋,鞠建華. 海洋放線菌S. erythraea SCSIO 07745中紅霉素衍生物及其生物合成基因簇的分析[J]. 中國海洋藥物,2018,37(05):1-12.
[14]紀(jì)曉奇,李青連,鞠建華. 融合表達氨基轉(zhuǎn)移酶DsaD和異構(gòu)酶DsaE合成L-別異亮氨酸[J]. 微生物學(xué)通報,2018,45(09):2006-2013.
[15]張善文,黃洪波,桂春,鞠建華. 海洋藥物及其研發(fā)進展[J]. 中國海洋藥物,2018,37(03):77-92.
[16]李宇,賴珍珠,李佳嶺,黃洪波,謝運昌,李文均,陶移文,鞠建華. 放線菌Streptomyces nojiriensis SCSIO m34-1吩嗪生物堿類次級代謝產(chǎn)物的研究[J]. 天然產(chǎn)物研究與開發(fā),2018,30(10):1663-1668+1705.
[17]賈艷璽,謝運昌,李青連,馬俊英,黃洪波,鞠建華. 海洋放線菌Streptomyces costaricanus SCSIO ZS0073中fungichromin生物合成基因簇的分析鑒定[J]. 中國海洋藥物,2017,36(06):1-10.
[18]宋現(xiàn)芹,蔣鑫,孫建彬,張春燕,張云,盧來春,鞠建華. 紅樹林放線菌Stremptmeces costaricanus SCSIO ZS0073抗菌活性次級代謝產(chǎn)物的研究[J]. 天然產(chǎn)物研究與開發(fā),2017,29(03):410-414.
[19]陳奇,秦湘靜,李青連,鞠建華. Marinacarbolines甲基化基因mcbD的篩選及其功能[J]. 微生物學(xué)報,2017,57(07):1095-1105.
[20]程偉鴿,桂春,鞠建華,李青連. 1株海洋來源Streptomyces sp.SCSIO 1682中那西肽(nosiheptide)的分離鑒定及其生物合成基因簇分析[J]. 中國海洋藥物,2016,35(06):7-14.
[21]鞠建華,周雪峰,朱偉明,漆淑華,徐剛明. 863課題“深海微生物活性物質(zhì)的挖掘及其利用技術(shù)”2013年度進展[J]. 科技資訊,2016,14(09):171-172.
[22]李宏志,劉靜,李青連,鞠建華. 抗感染海洋天然產(chǎn)物marformycin生物合成基因簇中調(diào)控基因及轉(zhuǎn)運基因的功能研究[J]. 中國海洋藥物,2016,35(01):10-18.
[23]張幸,桂春,田新朋,黃洪波,鞠建華. 海洋源放線菌Streptomyces sp.SCSIO 01681次級代謝產(chǎn)物的研究[J]. 中國海洋藥物,2015,34(06):35-40.
[24]羅明和,黃洪波,李沉紋,于彩平,馬俊英,盧來春,鞠建華. 海洋來源真菌Aspergillus sp.SCSIO 81-F2抗菌活性次級代謝產(chǎn)物的研究[J]. 天然產(chǎn)物研究與開發(fā),2015,27(02):241-245.
[25]紀(jì)昌濤,周瀟,陳奇,宋永相,黃洪波,王博,鞠建華. 2株海洋來源產(chǎn)淺藍霉素A的異壁放線菌的分離和鑒定[J]. 微生物學(xué)雜志,2015,35(01):24-29.
[26]羅明和,黃洪波,盧來春,鞠建華. 海洋真菌Eurotium amstelodami SCSIO 151二酮哌嗪吲哚生物堿類次生代謝產(chǎn)物的研究[J]. 天然產(chǎn)物研究與開發(fā),2015,27(01):50-54+147.
[27]唐桂嶺,黃洪波,王博,田新朋,鞠建華,宋永相. 南海深海鏈霉菌Streptomyces sp.SCSIO 5604次級代謝產(chǎn)物lyngbyatoxin A的研究[J]. 天然產(chǎn)物研究與開發(fā),2014,26(11):1767-1770+1892.
[28]謝運昌,鞠建華*. 綠灰霉素生物合成途徑中3-羥基吡啶甲酸起始結(jié)構(gòu)單元的活化特異性[J]. 微生物學(xué)報,2013,53(11):1179-1188.
[29]劉靜,羅明和,唐桂嶺,宋永相,田新朋,盧來春,鞠建華. 深海鏈霉菌Streptomyces sp.SCSIO 04777中腸道菌素的分離鑒定[J]. 中國海洋藥物,2013,32(05):7-13.
[30]張云,周瀟,宋永相,陳蕓蕓,黃洪波,李潔,華燕,鞠建華*. 南海深海鏈霉菌Streptomyces albiflaviniger SCSIO ZJ28中Elaiophylin的分離鑒定[J]. 天然產(chǎn)物研究與開發(fā),2013,25(02):185-189.
[31]周瀟,張云,黃洪波,宋永相,李潔,華燕,鞠建華*. 深海來源鏈霉菌Streptomyces griseorubens SCSIO ZY0206多酚蒽酮類代謝產(chǎn)物的研究[J]. 天然產(chǎn)物研究與開發(fā),2013,25(01):7-11.
[32]左佃光,馬俊英,王博,黃洪波,劉靜,張云,鞠建華*. 非核糖體肽類化合物的組合生物合成策略研究進展[J]. 中國抗生素雜志,2012,37(03):168-175.
[33]李軍,朱清華,張云,馬俊英,田新朋,李文均,張長生,鞠建華*. 深海放線菌Marinactinospora thermotolerans SCSIO 00652遺傳操作系統(tǒng)的建立[J]. 中國抗生素雜志,2012,37(02):105-111.
[34]胡濤,張光濤,朱義廣,李蘇梅,張海波,張改云,楊曉紅,鞠建華,張長生*. 友菌素核苷轉(zhuǎn)移酶amiE基因的克隆、表達和功能鑒定[J]. 微生物學(xué)報,2012,52(02):214-220.
[35]陳子明,汪中文,黃洪波,陳玉嬋,章衛(wèi)民,張長生,鞠建華*. 海洋真菌Xylaria sp.SOF11中細胞松弛素類化合物的研究[J]. 天然產(chǎn)物研究與開發(fā),2011,23(05):801-804.
[36]任香梅,黃洪波,劉靜,張云,馬俊英,王博,張長生,鞠建華*. 海洋鏈霉菌Streptomyces lusitanus SCSIO LR32中芳酰胺類代謝產(chǎn)物的研究[J]. 天然產(chǎn)物研究與開發(fā),2011,23(04):591-595.
[37]林欽恒,張光濤,李蘇梅,張海波,鞠建華,朱偉明,張長生*. 淺藍霉素產(chǎn)生菌海洋異壁放線菌WH1-2216-6遺傳操作體系的建立[J]. 微生物學(xué)報,2011,51(08):1032-1041.
[38]牛四文,李蘇梅,田新朋,胡濤,鞠建華,楊曉紅,張偲,張長生*. 海洋放線菌Streptomyces sp.SCSIO 1934中次生代謝產(chǎn)物的分離和鑒定[J]. 中國中藥雜志,2011,36(13):1763-1768.
[39]周俊勇,黃洪波,汪中文,楊民和,田新朋,張偲,張長生,鞠建華*. 海洋鏈霉菌Streptomyces sp.SCSIO 1667中吲哚咔唑生物堿類成分的研究[J]. 天然產(chǎn)物研究與開發(fā),2011,23(03):415-419.
[40]李軍,朱清華,馬俊英,王博,劉靜,張云,鞠建華*. 潮霉素A的生物合成研究進展[J]. 微生物學(xué)雜志,2011,31(02):69-74.
[41]李蘇梅,田新朋,牛四文,張文軍,張偲,鞠建華,張長生*. 南海鏈霉菌SCSIO 1635中抗霉素類化合物的分離鑒定(英文)[J]. 天然產(chǎn)物研究與開發(fā),2011,23(01):10-14+42.
[42]段傳人,姚月良,汪中文,田新朋,張偲,張長生,鞠建華*. 海洋鏈霉菌Streptomyces sp.SCSIO 1666活性代謝產(chǎn)物替達霉素A和B的發(fā)酵優(yōu)化及分離鑒定[J]. 中國海洋藥物,2010,29(06):12-20.
[43]羅明和,汪中文,黃洪波,朱清華,田新朋,白志川,張偲,張長生,鞠建華*. 海洋鏈霉菌Streptomyces sp. SCSIO 1672及其代謝產(chǎn)物水楊酸的分離鑒定[J]. 微生物學(xué)雜志,2010,30(06):22-26.
[44]肖毅,李蘇梅,馬亮,張改云,鞠建華,張長生*. 臺勾霉素生產(chǎn)菌指孢囊菌NRRL 18085遺傳操作體系的建立[J]. 微生物學(xué)報,2010,50(08):1014-1022.
[45]鄒忠杰,楊峻山*,鞠建華. 泥胡菜化學(xué)成分的研究[J]. 中草藥,2006,(09):1303-1304.
[46]鄒忠杰,楊峻山*,鞠建華. 泥胡菜的化學(xué)成分研究[J]. 中國中藥雜志,2006,(10):812-813.
[47]鄒忠杰,鞠建華,楊峻山*. 泥胡菜化學(xué)成分研究[J]. 中國藥學(xué)雜志,2006,(02):102-103.
[48]劉東,鞠建華,鄒忠杰,林耕,楊峻山. 西藏杓蘭中兩個新菲醌類化合物的分離與結(jié)構(gòu)鑒定(英文)[J]. 藥學(xué)學(xué)報,2005,(03):255-257.
[49]鞠建華,鄒忠杰*,楊峻山*. 褐花杓蘭化學(xué)成分的研究(英文)[J]. 中草藥,2004,35(02):20-22.
[50]鞠建華,周亮,林耕,劉東,王立為,楊峻山. 枇杷葉中三萜酸類成分及其抗炎、鎮(zhèn)咳活性研究[J]. 中國藥學(xué)雜志,2003,(10):24-29.
[51]鞠建華,周亮,鄭瑞霞,王春蘭,楊峻山. 高效液相色譜法測定中藥枇杷葉中熊果酸的含量[J]. 中國藥學(xué)雜志,2003, 38(9): 657-659.
[52]韓冰,沈彤,鞠建華,楊峻山. 淫羊藿屬植物化學(xué)成分研究概況[J]. 國外醫(yī)藥(植物藥分冊),2003,(04):151-153.
[53]劉東,鞠建華,楊峻山*. 狹葉崖爬藤化學(xué)成分的研究(英文)[J]. 中草藥,2003, 34(1): 4-6.
[54]鞠建華,林耕,楊峻山,逯海燕,馬柄娜,聶淑芹,張俠. 鐵破鑼皂苷O和P的結(jié)構(gòu)及其藥理活性[J]. 藥學(xué)學(xué)報,2002, 37(10): 788-792.
[55]韓冰,沈彤,鞠建華,楊峻山. 黔嶺淫羊藿的化學(xué)成分研究Ⅰ[J]. 中國藥學(xué)雜志, 2002, 37(5): 333-335.
[56]劉東,鞠建華,林耕,許旭東,楊峻山,涂光忠. 三葉崖爬藤中的新黃酮碳甙(英文)[J]. Acta Botanica Sinica,2002,(02):227-229.
[57]鞠建華,周亮,楊峻山. 二維核磁共振波譜在闡明一種三萜多糖皂苷結(jié)構(gòu)中的應(yīng)用[J]. 波譜學(xué)雜志,2001,18(04):329-341.
[58]鞠建華,劉東,林耕,許旭東,楊峻山,涂光忠,馬立斌. 中國特有藥用植物鐵破鑼中的新皂甙類成分(英文)[J]. 植物學(xué)報,2001,(09):983-987.
[59]鞠建華,劉東,楊峻山. 天然環(huán)菠蘿蜜烷型三萜皂苷類化合物的波譜學(xué)規(guī)律的探討[J]. 波譜學(xué)雜志,2001,18(01):79-90.
[60]鞠建華,劉東,楊峻山. 蘭科植物化學(xué)成分研究進展[J]. 國外醫(yī)藥(植物藥分冊),2000,(03):95-104.
[61]鞠建華,楊峻山,劉東. 鐵破鑼化學(xué)成分的研究Ⅱ[J]. 中國藥學(xué)雜志, 2000, 35(3): 157-160.
[62]林耕,許旭東,劉東,鞠建華,楊峻山.黃毛楤木化學(xué)成分的研究Ⅰ[J].中國藥學(xué)雜志,2000, 35(5): 298-300.
[63]林耕; 許旭東; 劉東; 鞠建華; 楊峻山.憽木皂苷C的結(jié)構(gòu)研究.中國藥學(xué)雜志, 2000, 35(5): 33-35.
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[67]鞠建華; 楊峻山.升麻族植物三萜皂甙的研究進展.中國中藥雜志, 1999, 24(9): 517-521.
發(fā)表會議論文：
[1]鞠建華. 海洋微生物抗感染藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成[A].第十一屆全國化學(xué)生物學(xué)學(xué)術(shù)會議論文摘要（第一卷）[C].,2019:203.
[2]鞠建華. 海洋微生物抗感染藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成[A]. 中國化學(xué)會第十二屆全國天然有機化學(xué)學(xué)術(shù)會議論文摘要集[C].2018:136.
[3]鞠建華. Discovery and engineered production of enhanced anti-tuberculosis ilamycins[A].第三屆中意活性天然產(chǎn)物研討會暨第一屆國際藥物化學(xué)論壇論文集[C].2017:47.
[4]鞠建華. 海洋微生物藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成[A].第十屆全國化學(xué)生物學(xué)學(xué)術(shù)會議報告摘要集[C].2017:129.
[5]鞠建華.Discovery and Biosynthesis of Anti-infective Cyclic Pepetides from Marine Actinomycetes.海洋藥物與天然藥物研究國際學(xué)術(shù)研討會, China,Guangxi Zhuang Autonomous Region,Nanning, 2015-11-23 to 2015-11-25.
[6]鞠建華.Discovery and Biosynthesis of Bioactive Natural Products from Marine Actinomycetes.2015' Yangling International Agri-Science Forum, 2015-11-05 to 2015-11-07.
[7]鞠建華.Deciphering the Biosynthetic Origin of L-allo-isoleucine.International Symposium on Biosystem and Biodesign Engineering 2015: Microbial Signal Regulation Network and Cell Factories, ISBBE 2015 , China,Shanghai, 2015-11-01 to 2015-11-03.
[8]鞠建華.海洋放線菌藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成.2015年中國微生物學(xué)會學(xué)術(shù)年會, 中國,湖北省,宜昌市, 2015-10-23至2015-10-25.
[9]鞠建華.Discovery and Biosynthesis of Anti-infective and Anti-tumor Natural Products from Marine-derived Actinomycetes.2015 International Conference on Greeen Pharmaceuticals, 2015-10-17 to 2015-10-18.
[10]鞠建華.Discovery and Biosynthesis of Anti-infective and Anti-tumor Natural Products from Marine Actinomycetes.Sino-German Symposium on Natural Product Sciences, China,Hubei,Wuhan, 2015-10-01 to 2015-10-06.
[11]鞠建華.海洋微生物藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成.中國化學(xué)會第九屆全國化學(xué)生物學(xué)學(xué)術(shù)會議, 中國,天津市, 2015-08-28至2015-08-31.
[12]鞠建華. 海洋放線菌抗感染、抗腫瘤藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成[A].中國化學(xué)會第十屆全國天然有機化學(xué)學(xué)術(shù)會議論文集——第三分會場：天然產(chǎn)物合成生物學(xué)、化學(xué)生物學(xué)及新技術(shù)[C].2014:15.
[13]馬俊英,周瀟,周俊超,張春燕,程偉鴿,陳奇,鞠建華. 抗感染環(huán)肽化合物Ilamycins生物合成基因簇的克隆及其后修飾基因的功能研究[A].中國化學(xué)會第十屆全國天然有機化學(xué)學(xué)術(shù)會議論文集——第三分會場：天然產(chǎn)物合成生物學(xué)、化學(xué)生物學(xué)及新技術(shù)[C].,2014:66.
[14]陳奇,紀(jì)昌濤,張云,宋永相,黃洪波,馬俊英,王博,李青蓮,鞠建華. 深海放線菌Actinoalloteichus sp.SCSIO ZJ63中β-咔啉生物堿類化合物的挖掘[A].2014年中國藥學(xué)大會暨第十四屆中國藥師周論文集[C].2014:167.
[15]桂春,黃洪波,宋永相,張幸,鞠建華. 深海來源放線菌Marinactinospora sp.LMJ08次級代謝產(chǎn)物的研究[A]. 2014年中國藥學(xué)大會暨第十四屆中國藥師周論文集[C].,2014:556.
[16]桂春; 李青連; 莫旭華; 謝運昌; 馬俊英; 鞠建華.一類新型Dieckmann環(huán)化酶功能的研究.第二屆中國放線菌生物學(xué)與產(chǎn)業(yè)化研討會, 2014-12-07.
[17]陳奇; 紀(jì)昌濤; 張云; 宋永相; 黃洪波; 馬俊英; 王博; 李青蓮; 鞠建華.深海放線菌Actinoalloteichus sp.SCSIO ZJ63中β-咔啉生物堿類化合物的挖掘.2014年中國藥學(xué)大會暨第十四屆中國藥師周論文集.
[18]張春燕,馬俊英,鞠建華. 抗感染抗生素Ilamycins生物合成基因簇的克隆及其功能研究[A].2014年中國藥學(xué)大會暨第十四屆中國藥師周論文集[C].2014:2858-2859.
[19]劉晴,張永光,桂春,宋永相,黃洪波,李文均,鞠建華. 耐堿放線菌Nocardiopsis sp.EGI80425中安莎菌素的分離及鹵素喂養(yǎng)實驗的探索[A].2014年中國藥學(xué)大會暨第十四屆中國藥師周論文集[C].2014:3294.
[20]程偉鴿,李青連,鞠建華. 海洋來源鏈霉菌屬SCSIO 3406中phenaziterpene的生物合成研究[A].2014年中國藥學(xué)大會暨第十四屆中國藥師周論文集[C].2014:220.
[21]賈艷璽,張龍霞,張善文,李潔,閆素君,鞠建華,宋永相. 海洋放線菌SCSIO13263抗耐藥性細菌活性次級代謝產(chǎn)物的研究[A].2014年中國藥學(xué)大會暨第十四屆中國藥師周論文集[C].2014:783.
[22]李宏志,馬俊英,李青連,鞠建華. Himstatin生物合成基因簇中肽單加氧酶HmtM的功能研究[A].2014年中國藥學(xué)大會暨第十四屆中國藥師周論文集[C].2014:925.
[23]鞠建華.Discovery and Biosynthesis of Anti-infective and Anti-tumor Natural Products from Marine Actinomycetes.第二屆中國放線菌生物學(xué)與產(chǎn)業(yè)化研討會, China,Guangdong,Guangzhou, 2014-12-07 to 2014-12-09.
[24]鞠建華.Anti-infective and Anti-tumor Natural Products Discovery and Biosynthesis from Marine Actinomycetes.3rd Annual conference of the International Chemical Biology Society, United States, 2014-11-17 to 2014-11-19.
[25]陳奇,馬俊英,朱清華,紀(jì)昌濤,鞠建華. 深海放線菌Marinactinospora thermotolerans SCSIO 00652抗感染、抗腫瘤藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成[A].第八屆全國化學(xué)生物學(xué)學(xué)術(shù)會議論文摘要集[C].2013:173.
[26] 鞠建華.Anti-infective and Anti-tumor Natural Products Discovery and Biosynthesis from Marine Actinomycetes and Fungi.Sino-Swiss Stepping Stone Symposium on Natural Products and Drug Discovery, China,Shanghai, 2013-10-23 to 2013-10-26.
[27]鞠建華.海洋微生物特征代謝產(chǎn)物的生物合成.第十一屆海洋藥物學(xué)術(shù)年會, 中國,海南省,�？谑�, 2013-10-18至2013-10-20
[28]鞠建華,馬俊英,黃洪波,宋永相,王博,朱清華,莫旭華,周瀟. 海洋微生物活性次級代謝產(chǎn)物的發(fā)現(xiàn)及其生物合成[A].第四屆全國微生物資源學(xué)術(shù)暨國家微生物資源平臺運行服務(wù)研討會論文集[C].2012:18-19.
[29]鞠建華.Discovery and Biosynthesis of Bioactive Natural Products from the Deep South China Sea-derived Marinactinospora thermotolerans SCSIO 00652.IOCD International Conference on Functional Molecules in Nature, China,Jiangsu,Nanjing, 2012-09-22 to 2012-09-24.
[30]黃洪波,陳子明,姚月良,羅明和,任香梅,周俊勇,馬俊英,王博,宋永相,張長生,鞠建華. 海洋微生物活性先導(dǎo)化合物的發(fā)現(xiàn)及其生物活性研究[A].2011年中國藥學(xué)大會暨第11屆中國藥師周論文集[C].2011:111-119.
[31]張改云,李蘇梅,牛四文,胡濤,肖毅,鞠建華,張長生. 二糖核苷類抗生素友菌素的生物合成研究[A]. 中國化學(xué)會第八屆天然有機化學(xué)學(xué)術(shù)研討會論文集[C].2010:104.
[32]鞠建華. 深海放線菌新屬Marinactinospora thermotolerans中抗菌、抗腫瘤活性先導(dǎo)化合物的發(fā)現(xiàn)、生物合成和工程改造[A].中國化學(xué)會第八屆天然有機化學(xué)學(xué)術(shù)研討會論文集[C].,2010:41.
[33]莫旭華,汪中文,姚月良,馬俊英,王博,黃洪波,張長生,鞠建華. 替達霉素生物合成基因簇的克隆及其生物合成機制研究[A].2010年第四屆全國微生物遺傳學(xué)學(xué)術(shù)研討會論文摘要集[C].,2010:91.
[34]肖毅,李蘇梅,牛四文,馬亮,胡濤,張改云,張光濤,鞠建華,張長生. 新型抗菌劑臺勾霉素的生物合成研究[A]..2010年第四屆全國微生物遺傳學(xué)學(xué)術(shù)研討會論文摘要集[C].2010:30.
[35]鞠建華,張長生. 海洋微生物活性先導(dǎo)化合物的發(fā)現(xiàn)及其組合生物合成[A].第七屆全國天然有機化學(xué)學(xué)術(shù)研討會論文集[C].2008:154-155.
[36]鞠建華,王平,李志忠,王永江,張登榮,趙繼成,葛榜軍,朱博勤,黨福星,楊日紅. “十五”期間國土資源遙感科技進展[A].“十五”重要地質(zhì)科技成果暨重大找礦成果交流會材料一——“十五”地質(zhì)行業(yè)各部門地質(zhì)與找礦成果綜述[C].,2006:15-23.
[37]鞠建華,李志忠. 前言[A].全國國土資源與環(huán)境遙感技術(shù)應(yīng)用交流會論文文集[C].2004:3-4.
[38]鞠建華,宋宏儒,周萍.我國西南地區(qū)石漠化現(xiàn)狀遙感調(diào)查[A].全國國土資源與環(huán)境遙感技術(shù)應(yīng)用交流會論文文集[C],2004:21-24.
[39]馬立斌,涂光忠,安冬各,鞠建華,劉東,林耕,許旭東,楊峻山. 中國特有藥用植物鐵破鑼中新六糖皂甙結(jié)構(gòu)的確定[A].第十一屆全國波譜學(xué)學(xué)術(shù)會議論文摘要集[C].2000:77-78.
[40]許旭東,劉東,鞠建華,林耕,楊峻山. 安徽楤木中三個新的常春藤三萜皂甙[A]. 國際傳統(tǒng)醫(yī)藥大會論文摘要匯編[C].2000:425.
[41]許旭東,劉東,鞠建華,林耕,楊峻山. 安徽楤木中三個新的齊墩果酸型三萜皂甙[A]. .國際傳統(tǒng)醫(yī)藥大會論文摘要匯編[C].2000:425-426.
鞠建華，男，1972年生，博士，現(xiàn)任山東大學(xué)藥學(xué)院院長，教授，博士生導(dǎo)師。1995年畢業(yè)于山東醫(yī)科大學(xué)藥學(xué)系，獲理學(xué)學(xué)士學(xué)位；2000年畢業(yè)于中國協(xié)和醫(yī)科大學(xué)（現(xiàn)北京協(xié)和醫(yī)學(xué)院），獲理學(xué)博士學(xué)位。先后在中國醫(yī)學(xué)科學(xué)院（2000.08-2003.02）、美國威斯康星-麥迪遜大學(xué)藥學(xué)院（2003.03-2008.02）和中國科學(xué)院南海海洋研究所（2008.03-2021）工作。主要從事(海洋)微生物活性次級代謝產(chǎn)物的發(fā)現(xiàn)、生物合成和抗感染、抗腫瘤創(chuàng)新藥物研發(fā)工作，從(海洋)微生物中發(fā)現(xiàn)了具有抗感染、抗腫瘤等活性天然產(chǎn)物1000余個，開發(fā)了海洋微生物的組合生物合成和異源表達技術(shù)，闡明了20余種特征活性代謝產(chǎn)物的生物合成機制，揭示了咔啉堿合成酶、Dieckmann縮合酶、Diels-Alder環(huán)化酶、別異亮氨酸異構(gòu)酶、細胞色素P450氧化酶、L-半乳糖變構(gòu)酶等26種新穎生物合成酶的催化功能，篩選出3個自主產(chǎn)權(quán)的抗結(jié)核桿菌感染、抗膠質(zhì)瘤和抗白血病候選海洋藥物，其中1個在系統(tǒng)臨床前研究。主持國家重點研發(fā)計劃、國家自然科學(xué)基金重點、NSFC-廣東聯(lián)合基金重點項目等20余項。獲得第五屆施維雅青年藥物化學(xué)獎、第七屆藥明康德生命化學(xué)研究獎�，F(xiàn)任中國藥學(xué)會海洋藥物專業(yè)委員會副主任委員；中國微生物學(xué)會海洋微生物專業(yè)委員會副主任委員；國際學(xué)術(shù)刊物J. Nat. Prod.、Mar. Drugs顧問編委，中國海洋藥物編委。2008年入選中科院人才學(xué)者，2014年獲得國家杰出青年科學(xué)基金、同年入選科技部“創(chuàng)新人才推進計劃”中青年科技創(chuàng)新領(lǐng)軍人才，2016年入選國家特支計劃科技創(chuàng)新領(lǐng)軍人才和廣東特支計劃“南粵百杰”杰出人才, 2020年入選國務(wù)院特殊津貼專家。在Nat. Chem. Biol.,Nature Commun.,PNAS、J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Org. lett.,J. Nat. Prod.等學(xué)術(shù)刊物發(fā)表論文208篇，論文被SCI引用超過5000次，獲授權(quán)專利24項。 
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